Intranasal oxytocin as strategy for medication-enhanced psychotherapy of PTSD: salience processing and fear inhibition processes
About ten percent of people experiencing a traumatic event will subsequently develop post-
traumatic stress disorder (PTSD). PTSD is characterized by an exaggerated fear response …
traumatic stress disorder (PTSD). PTSD is characterized by an exaggerated fear response …
[HTML][HTML] Chronic and acute intranasal oxytocin produce divergent social effects in mice
H Huang, C Michetti, M Busnelli, F Manago… - …, 2014 - nature.com
Intranasal administration of oxytocin (OXT) might be a promising new adjunctive therapy for
mental disorders characterized by social behavioral alterations such as autism and …
mental disorders characterized by social behavioral alterations such as autism and …
[HTML][HTML] Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques
MR Lee, TA Shnitko, SW Blue, AV Kaucher… - Nature …, 2020 - nature.com
Oxytocin may have promise as a treatment for neuropsychiatric disorders. Its therapeutic
effect may depend on its ability to enter the brain and bind to the oxytocin receptor. To date …
effect may depend on its ability to enter the brain and bind to the oxytocin receptor. To date …
Oxytocin facilitates the sensation of social stress
M Eckstein, D Scheele, K Weber… - Human brain …, 2014 - Wiley Online Library
Essentially all social species experience social stress which can be a catalyst for detriments
in mental and physical health. The neuropeptide oxytocin (OXT) has been shown to produce …
in mental and physical health. The neuropeptide oxytocin (OXT) has been shown to produce …
Effects of intranasal oxytocin on emotional face processing in women
The neuropeptide oxytocin (OXT) has previously been found to reduce amygdala reactivity
to social and emotional stimuli in healthy men. The present study aimed to investigate the …
to social and emotional stimuli in healthy men. The present study aimed to investigate the …
Oxytocin facilitates protective responses to aversive social stimuli in males
N Striepens, D Scheele, KM Kendrick… - Proceedings of the …, 2012 - National Acad Sciences
The neuropeptide oxytocin (OXT) can enhance the impact of positive social cues but may
reduce that of negative ones by inhibiting amygdala activation, although it is unclear …
reduce that of negative ones by inhibiting amygdala activation, although it is unclear …
Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice
ID Neumann, R Maloumby, DI Beiderbeck… - …, 2013 - Elsevier
The possibility to improve socio-emotional behaviors in humans by intranasal administration
of synthetic oxytocin (OXT) attracts increasing attention, but its uptake into the brain has …
of synthetic oxytocin (OXT) attracts increasing attention, but its uptake into the brain has …
Oxytocin influences processing of socially relevant cues in the ventral tegmental area of the human brain
SE Groppe, A Gossen, L Rademacher, A Hahn… - Biological …, 2013 - Elsevier
Background Evidence accumulates that the neuropeptide oxytocin plays an important role in
mediating social interaction among humans and that a dysfunction in oxytocin-modulated …
mediating social interaction among humans and that a dysfunction in oxytocin-modulated …
[HTML][HTML] In the nose or on the tongue? Contrasting motivational effects of oral and intranasal oxytocin on arousal and reward during social processing
Intranasal oxytocin exerts wide-ranging effects on socioemotional behavior and is proposed
as a potential therapeutic intervention in psychiatric disorders. However, following intranasal …
as a potential therapeutic intervention in psychiatric disorders. However, following intranasal …
[HTML][HTML] Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder
The neuropeptide oxytocin (OXT) is thought to attenuate anxiety by dampening amygdala
reactivity to threat in individuals with generalized social anxiety disorder (GSAD). Because …
reactivity to threat in individuals with generalized social anxiety disorder (GSAD). Because …