Intranasal oxytocin as strategy for medication-enhanced psychotherapy of PTSD: salience processing and fear inhibition processes

SBJ Koch, M van Zuiden, L Nawijn, JL Frijling… - …, 2014 - Elsevier
About ten percent of people experiencing a traumatic event will subsequently develop post-
traumatic stress disorder (PTSD). PTSD is characterized by an exaggerated fear response …

[HTML][HTML] Chronic and acute intranasal oxytocin produce divergent social effects in mice

H Huang, C Michetti, M Busnelli, F Manago… - …, 2014 - nature.com
Intranasal administration of oxytocin (OXT) might be a promising new adjunctive therapy for
mental disorders characterized by social behavioral alterations such as autism and …

[HTML][HTML] Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques

MR Lee, TA Shnitko, SW Blue, AV Kaucher… - Nature …, 2020 - nature.com
Oxytocin may have promise as a treatment for neuropsychiatric disorders. Its therapeutic
effect may depend on its ability to enter the brain and bind to the oxytocin receptor. To date …

Oxytocin facilitates the sensation of social stress

M Eckstein, D Scheele, K Weber… - Human brain …, 2014 - Wiley Online Library
Essentially all social species experience social stress which can be a catalyst for detriments
in mental and physical health. The neuropeptide oxytocin (OXT) has been shown to produce …

Effects of intranasal oxytocin on emotional face processing in women

G Domes, A Lischke, C Berger, A Grossmann… - …, 2010 - Elsevier
The neuropeptide oxytocin (OXT) has previously been found to reduce amygdala reactivity
to social and emotional stimuli in healthy men. The present study aimed to investigate the …

Oxytocin facilitates protective responses to aversive social stimuli in males

N Striepens, D Scheele, KM Kendrick… - Proceedings of the …, 2012 - National Acad Sciences
The neuropeptide oxytocin (OXT) can enhance the impact of positive social cues but may
reduce that of negative ones by inhibiting amygdala activation, although it is unclear …

Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice

ID Neumann, R Maloumby, DI Beiderbeck… - …, 2013 - Elsevier
The possibility to improve socio-emotional behaviors in humans by intranasal administration
of synthetic oxytocin (OXT) attracts increasing attention, but its uptake into the brain has …

Oxytocin influences processing of socially relevant cues in the ventral tegmental area of the human brain

SE Groppe, A Gossen, L Rademacher, A Hahn… - Biological …, 2013 - Elsevier
Background Evidence accumulates that the neuropeptide oxytocin plays an important role in
mediating social interaction among humans and that a dysfunction in oxytocin-modulated …

[HTML][HTML] In the nose or on the tongue? Contrasting motivational effects of oral and intranasal oxytocin on arousal and reward during social processing

J Kou, C Lan, Y Zhang, Q Wang, F Zhou, Z Zhao… - Translational …, 2021 - nature.com
Intranasal oxytocin exerts wide-ranging effects on socioemotional behavior and is proposed
as a potential therapeutic intervention in psychiatric disorders. However, following intranasal …

[HTML][HTML] Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder

SM Gorka, DA Fitzgerald, I Labuschagne… - …, 2015 - nature.com
The neuropeptide oxytocin (OXT) is thought to attenuate anxiety by dampening amygdala
reactivity to threat in individuals with generalized social anxiety disorder (GSAD). Because …