[HTML][HTML] CSF and blood oxytocin concentration changes following intranasal delivery in macaque

O Dal Monte, PL Noble, J Turchi, A Cummins… - PloS one, 2014 - journals.plos.org
Oxytocin (OT) in the central nervous system (CNS) influences social cognition and behavior,
making it a candidate for treating clinical disorders such as schizophrenia and autism …

[HTML][HTML] Modulation of resting-state amygdala-frontal functional connectivity by oxytocin in generalized social anxiety disorder

S Dodhia, A Hosanagar, DA Fitzgerald… - …, 2014 - nature.com
Generalized social anxiety disorder (GSAD) is characterized by aberrant patterns of
amygdala-frontal connectivity to social signals of threat and at rest. The neuropeptide …

Oxytocin delivered nasally or intraperitoneally reaches the brain and plasma of normal and oxytocin knockout mice

AS Smith, AC Korgan, WS Young - Pharmacological research, 2019 - Elsevier
Intranasal delivery of oxytocin (Oxt) has been identified as a potential therapeutic to target
human conditions characterized by social deficits, yet the ability of this administrative route …

Intranasal oxytocin administration is reflected in human saliva

O Weisman, O Zagoory-Sharon, R Feldman - Psychoneuroendocrinology, 2012 - Elsevier
Following the discovery that intranasal administration of neuropeptides can reach the central
nervous system, a growing number of studies applied intranasal oxytocin (OT) paradigms to …

[HTML][HTML] Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women

RAI Bethlehem, MV Lombardo, MC Lai… - Translational …, 2017 - nature.com
Oxytocin may influence various human behaviors and the connectivity across subcortical
and cortical networks. Previous oxytocin studies are male biased and often constrained by …

Do delivery routes of intranasally administered oxytocin account for observed effects on social cognition and behavior? A two-level model

DS Quintana, GA Alvares, IB Hickie… - … & Biobehavioral Reviews, 2015 - Elsevier
Accumulating evidence demonstrates the important role of oxytocin (OT) in the modulation of
social cognition and behavior. This has led many to suggest that the intranasal …

Overview of human oxytocin research

KM Kendrick, AJ Guastella, B Becker - Behavioral pharmacology of …, 2018 - Springer
Social dysfunction is a core symptom of many psychiatric disorders and current medications
have little or no remedial effects on this. Following on from extensive studies on animal …

[HTML][HTML] The impact of a single administration of intranasal oxytocin on the recognition of basic emotions in humans: a meta-analysis

S Shahrestani, AH Kemp, AJ Guastella - Neuropsychopharmacology, 2013 - nature.com
Many studies have highlighted the potential of oxytocin (OT) to enhance facial affect
recognition in healthy humans. However, inconsistencies have emerged with regard to the …

[HTML][HTML] Nasal oxytocin for the treatment of psychiatric disorders and pain: achieving meaningful brain concentrations

DC Yeomans, LR Hanson, DS Carson… - Translational …, 2021 - nature.com
There is evidence of the therapeutic potential of intranasal oxytocin for the treatment of pain
and various psychiatric disorders, however, there is scant evidence that oxytocin reaches …

Intranasal oxytocin administration attenuates the ACTH stress response in monkeys

KJ Parker, CL Buckmaster, AF Schatzberg… - …, 2005 - Elsevier
Social relationships protect against the development of stress-related psychiatric disorders,
yet little is known about the neurobiology that regulates this phenomenon. Recent evidence …