Objective Youth-onset type 2 diabetes (T2D) is physiologically distinct from adult-onset, but it
is not clear how the two diseases differ at a molecular level. In utero exposure to maternal …

Background Intrauterine exposure to a disturbed maternal glucose metabolism is associated
with adverse offspring outcomes. DNA methylation is a potential mechanism underlying …

Given the differential risk of type 1 diabetes (T1D) in offspring of affected fathers versus
affected mothers and our observation that T1D cases have differential DNA methylation near …

Aims/hypothesis Individuals exposed to maternal diabetes in utero are more likely to
develop metabolic and cardiovascular diseases later in life. This may be partially attributable …

Background Gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) share
many pathophysiological factors including genetics, but whether epigenetic marks are …

Background Fetal exposure to hyperglycemia impacts negatively kidney development and
function. Objective Our objective was to determine whether fetal exposure to moderate …

Background In utero exposure to diabetes has been shown to contribute to preterm birth,
though the underlying biological mechanisms are yet to be fully elucidated. Fetal epigenetic …

Investigators of previous cross-sectional epigenome-wide association studies (EWAS) in
adults have reported hundreds of 5′-cytosine-phosphate-guanine-3′(CpG) sites …

Offspring of women with gestational diabetes mellitus (GDM) are at increased risk of
developing metabolic disease, potentially mediated by epigenetic mechanisms. We …

OBJECTIVE Maternal glycemic dysregulation during pregnancy increases the risk of
adverse health outcomes in her offspring, a risk thought to be linearly related to maternal …