Sickle cell anemia (SCA) is both a triumph of modern medicine and a frustrating example of
the slow pace of translational biomedical research. We have known the precise molecular …

This article summarizes my presentation at the Pediatric Hematology‐Oncology Symposium
in honor of Dr. Stephen A. Feig in April 2005. Areas highlighted reflect key topics whose …

Sickle cell anemia is present in about 1 in 600 Black Americans at birth. It claims the life of
many infants, causes pain and suffering in adults, and usually culminates in premature …

Although sickle cell anemia was the first molecular disease to be identified, its complex and
fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin …

Children with sickle cell disease (SCD) have varied clinical problems. The hallmark
manifestation of SCD, the pain crisis, typically first occurs in early childhood presenting as …

As more children are appropriately being diagnosed, the burden of sickle cell disease is
increasing greatly in Africa and in high-resource countries such as the United States and …

Sickle Cell Anemia and Related Hemoglobinopathies Page 1 Sickle Cell Anemia and Related
Hemoglobinopathies Elliott P. Vichinsky, MD,* and Bertram H. Lubin, MDt SICKLE CELL …

Over the past 2 years, substantial attention has been given by academic institutions, the
National Institutes of Health, and the media to the November 2010 centennial of Dr. James …

Sickle cell disease (SCD) is one of the most common genetic disorders worldwide. It is
caused by a point mutation that changes glutamic acid (Glu6) to valine (Val6) in the β chain …

Sickle cell disease (SCD) is a group of related disorders that share a common genetic
cause: sickle hemoglobin (Hgb S). SCD occurs in persons who are homozygous for Hgb S …