The signaling molecule nitric oxide (NO) mediates many of its effects by the stimulation of
soluble guanylyl cyclase (sGC). The activation process is initiated by high-affinity binding of …

The heterodimeric heme-protein soluble guanylyl cyclase (sGC) is the only proven receptor
for nitric oxide (NO). Recently, two different types of NO-independent soluble guanylyl …

Significance: Soluble guanylyl/guanylate cyclase (sGC) is the primary receptor for nitric
oxide (NO) and is central to the physiology of blood pressure regulation, wound healing …

Soluble guanylate cyclase (sGC) is the receptor for nitric oxide (NO) in human. It is an
important validated drug target for cardiovascular diseases. sGC can be pharmacologically …

Soluble guanylate cyclase (sGC) is a heme-containing heterodimeric enzyme that generates
many molecules of cGMP in response to its ligand nitric oxide (NO); sGC thereby acts as an …

Soluble guanylate cyclase (sGC) is a receptor for nitric oxide (NO). Binding of NO to ferrous
(Fe 2+) heme increases its catalytic activity, leading to the production of cGMP from GTP …

The heme-enzyme soluble guanylyl cyclase (sGC) is an ubiquitous NO receptor, which
mediates NO downstream signaling by the generation of cGMP. We studied the mechanism …

Nitric oxide (NO)-sensitive soluble guanylyl cyclase (sGC), an enzyme that catalyzes the
conversion of guanosine-5′-triphosphate (GTP) to cyclic guanosine-3′, 5 …

Direct stimulation of soluble guanylate cyclase (sGC) represents a promising therapeutic
strategy for the treatment of a range of diseases, including the severely disabling pulmonary …

It is now well established that the NO-sGC-cGMP signal transduction system mediates many
different physiological functions in almost every conceivable organ system; this has been …