Asthma is a heterogeneous and complex condition characterized by chronic airway
inflammation, which may be clinically stratified into three main phenotypes: type 2 (T2) low …

Asthma is a heterogeneous disease with many phenotypes, and age at disease onset is an
important factor in separating the phenotypes. Genetic factors, atopy, and early respiratory …

In many asthmatics, chronic airway inflammation is driven by IL-4-, IL-5-, and IL-13-
producing Th2 cells or ILC2s. Type 2 cytokines promote hallmark features of the disease …

Asthma is the most common chronic pediatric lung disease that has traditionally been
defined as a syndrome of airway inflammation characterized by clinical symptoms of cough …

Severe asthma is a heterogeneous disease with different phenotypes based on clinical,
functional or inflammatory parameters. In particular, the eosinophilic phenotype is …

Traditionally, asthma and allergic diseases have been defined by broad definitions and
treated with nonspecific medications, including corticosteroids and bronchodilators. There is …

Background The pathogenesis of severe asthma in childhood remains poorly understood.
Objective We sought to construct the immunologic landscape in the airways of children with …

The term asthma encompasses a disease spectrum with mild to very severe disease
phenotypes whose traditional common characteristic is reversible airflow limitation. Unlike …

Patients with severe asthma have asthma symptoms which are difficult to control, require
high dosages of medication, and continue to experience persistent symptoms, asthma …

Although patients with “severe” asthma tend to be characterized by ongoing symptoms and
airway inflammation despite treatment with high doses of inhaled and systemic …