The recent Lancet commission has highlighted that “asthma” should be used to describe a
clinical syndrome of wheeze, breathlessness, chest tightness, and sometimes cough. The …

▪ Abstract Asthma is a chronic disorder of the airways that is characterized by reversible
airflow obstruction and airway inflammation, persistent airway hyperreactivity, and airway …

Asthma is a chronic inflammatory airway disease associated with type 2 cytokines
interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus …

Asthma is one of the most common chronic immunological diseases in humans, affecting
people from childhood to old age. Progress in treating asthma has been relatively slow and …

Objectives To review current thinking regarding the role of personalized phenotype-driven
as opposed to broad guideline-based therapies in asthma and to speculate on the relative …

The last 2 years yielded a proliferation of high-quality asthma research. These include new
understandings of the incidence and natural history of asthma, findings on the effects of …

The complexity of asthma is underscored by the number of cell types and mediators
implicated in the pathogenesis of this heterogeneous syndrome. Type 2 CD4+ T-cells (Th2) …

For more than a century, clinicians have attempted to subdivide asthma into different
phenotypes based on triggers that cause asthma attacks, the course of the disease, or the …

BACKGROUND: The pathology of pediatric severe therapy-resistant asthma (STRA) is little
understood. OBJECTIVES: We hypothesized that STRA in children is characterized by …

Asthma is a common disease in paediatrics and adults with a significant morbidity, mortality,
and financial burden worldwide. Asthma is now recognized as a heterogeneous disease …