This report will give a general overview of some of the in vitro methodologies used in toxicity
testing. The use of computer-based structure-activity relationships and cell culture testing …

High throughput toxicological estimation is required for safety evaluation in the early stage of
drug discovery. In this context, establishment of an in vitro screening system reflecting in vivo …

The new strategies for development of pharmacologically interesting compounds pose some
limitations for standard toxicity assessment approaches due to:(1) increase in the number of …

In vitro liver preparations are increasingly used for the study of hepatotoxicity of chemicals.
In recent years their actual advantages and limitations have been better defined. The cell …

Toxicity testing is required for new chemicals being introduced onto the market. The use of
animals in evaluating chemical safety is costly and time consuming. Furthermore, there is …

The application of in vitro models in evaluating the toxicity of toxicants has enhanced our
limited understanding of drugs and chemical-induced toxicity. From the public perspective …

Approaches to the evaluation of drug and other chemical toxicity with mammalian cell
culture systems are designed to enhance the predictability of animal models. Identification of …

An in vitro test battery is described which consists of five systems using different types of
cells:(1) bovine sperm cells,(2) Balb/c 3T3 cells,(3) primary cultures of rat hepatocytes,(4) …

The basis for the prediction of toxicity from chemical structure is that the properties of a
chemical are implicit in its molecular structure. Biological activity can be expressed as a …

Isolated hepatocyte systems are being examined in our laboratory for a number of
applications, including alternatives to animal test ing. This report summarizes findings from …