Hormonal regulation is essential to spermatogenesis. Sertoli cells (SCs) have functions that
reach far beyond the physical support of germ cells, as they are responsible for creating the …

Sertoli cells play a central role in spermatogenesis. They maintain the blood-testis barrier,
an essential feature of seminiferous tubules which creates the proper environment for the …

The functions of Sertoli cells in spermatogenesis have attracted much more attention
recently. Normal spermatogenesis depends on Sertoli cells, mainly due to their influence on …

Sertoli cells are somatic cells present in seminiferous tubules which have essential roles in
regulating spermatogenesis. Considering that each Sertoli cell is able to support a limited …

Sertoli cells are the somatic cells of the testis that are essential for testis formation and
spermatogenesis. Sertoli cells facilitate the progression of germ cells to spermatozoa via …

Male factor infertility is increasing in developed countries, and several factors linked to
lifestyle have been shown to negatively affect spermatogenesis. Sertoli cells are pivotal to …

A healthy man typically produces between 50× 10 6 and 200× 10 6 spermatozoa per day by
spermatogenesis; in the absence of Sertoli cells in the male gonad, this individual would be …

Sustaining and maintaining the intricate process of spermatogenesis is liable upon
hormones and growth factors acting through endocrine and paracrine pathways. The Sertoli …

Testosterone and follicle-stimulating hormone (FSH) are required to obtain full reproductive
potential. In the testis, somatic Sertoli cells transduce signals from testosterone and FSH into …

Whereas spermatogonia stem cells continually divide to populate the testis with developing
germ cells, the major supporter of this process, the Sertoli cell, ceases to proliferate shortly …