The serum anion gap in the evaluation of acid-base disorders: what are its limitations and can its effectiveness be improved?

JA Kraut, GT Nagami - Clinical Journal of the American Society of …, 2013 - journals.lww.com
The serum anion gap has been utilized to identify errors in the measurement of electrolytes,
to detect paraproteins, and, most relevant to the nephrologist, to evaluate patients with …

Serum anion gap: its uses and limitations in clinical medicine

JA Kraut, NE Madias - Clinical journal of the American Society of …, 2007 - journals.lww.com
The serum anion gap, calculated from the electrolytes measured in the chemical laboratory,
is defined as the sum of serum chloride and bicarbonate concentrations subtracted from the …

Gaps in the anion gap

MM Salem, SK Mujais - Archives of internal medicine, 1992 - jamanetwork.com
Objective.—To review limitations of the use of serum anion gap in clinical practice. Data
Sources.—Original reports and reviews. Study Selection.—Sources containing the most …

The anion gap: its use in quality control.

DL Witte, JL Rodgers, DA Barrett 2nd - Clinical chemistry, 1976 - academic.oup.com
Because the anion gap is useful in classifying acid-base disorders, quantitative information
on this variable should be readily available. Three populations were studied and means and …

Clinical utility of anion gap in deciphering acid–base disorders

P Reddy, AD Mooradian - International Journal of Clinical …, 2009 - Wiley Online Library
The anion gap (AG) measurement is a very useful tool in the evaluation of patients with acid–
base disorders. Once metabolic acidosis is identified, AG will provide the important first step …

The fall of the serum anion gap

SD Winter, JR Pearson, PA Gabow… - Archives of internal …, 1990 - jamanetwork.com
• Using modern electrode technology (Beckman ASTRA analyzer), we evaluated the
reference range for the anion gap (calculated as sodium minus chloride minus bicarbonate …

Use of the ΔAG/ΔHCO3− Ratio in the diagnosis of mixed acid-base Disorders

A Rastegar - Journal of the American Society of Nephrology, 2007 - journals.lww.com
When a strong acid is added to plasma, one expects a quantitative relationship between
excess anion gap (ΔAG) and bicarbonate deficit (ΔHCO 3−) with the ΔAG/ΔHCO 3− ratio …

Value of the anion gap in clinical diagnosis and laboratory evaluation.

PH Lolekha, S Lolekha - Clinical chemistry, 1983 - academic.oup.com
We report the incidence of normal (50.4%), increased (46.7%), and decreased (2.9%) anion
gap among hospitalized patients in a retrospective study. The mean and range of increased …

Anion-gap interpretation: the old and the new

M Emmett - Nature clinical practice nephrology, 2006 - nature.com
The plasma concentration of sodium ions normally exceeds the sum of the plasma
concentrations of chloride and bicarbonate ions. Calculation of the resulting'anion gap'can …

Diagnostic importance of an increased serum anion gap

PA Gabow, WD Kaehny, PV Fennessey… - … England Journal of …, 1980 - Mass Medical Soc
Fifty-seven hospitalized patients with increased serum anion gaps, defined as
[Na]−([Cl]+[HCO3]), were studied to explore the biochemical basis and the diagnostic …