Chemokines are key players of the cancer-related inflammation. Chemokine ligands and
receptors are downstream of genetic events that cause neoplastic transformation and are …

The chemokine system has evolved primarily to control the trafficking of leukocytes during
immune or inflammatory responses. However, through their expression of chemokine …

Tumor development and progression are multifactorial processes, regulated by a large
variety of intrinsic and microenvironmental factors. A key role in cancer is played by …

Cancer cells, endothelial cells, inflammatory cells and various cytokines form a part of the
tumor microenvironment (TME). Chemokines constitute the largest family of cytokines, and …

Inappropriate chemokine/receptor expression or regulation is linked to many diseases,
especially those characterized by an excessive cellular infiltrate, such as rheumatoid arthritis …

Cancer is a miscellany of diseases that involves uncontrolled growth and proliferation of
neoplastic cells; they originate from normal cells that undergo genetic and epigenetic …

Leukocyte infiltration into inflamed or injured tissues is regulated by a variety of cell-
associated and soluble factors that mediate the communications between circulating …

Chemokines (ie, chemoattractant cytokines) are a family of small secreted molecules that
mediate leukocyte migration. It is becoming increasingly more evident that chemokines play …

Cytokines are small-molecular-weight, proteinaceous, immunomodulating molecules that
are crucial for controlling the growth and activity of blood and other immune cells. They are …

The chemokine system, comprising 48 chemokines and 23 receptors, is critically involved in
several hallmarks of cancer. Yet, despite extensive efforts from the pharmaceutical sector …