Leukocyte trafficking is mainly governed by chemokines, chemotactic cytokines, which can
be concomitantly produced in tissues during homeostatic conditions or inflammation. After …

From a historical perspective, RNA tumor viruses were among the first viruses to give us
clues to normal cellular gene function by their acquisition of host DNA. Homologues of …

Chemokines govern leukocyte migration by attracting cells that express their cognate
ligands. Many cancer types show altered chemokine secretion profiles, favoring the …

The chemokines are a family of chemotactic cytokines that mediate their activity by acting on
seven-transmembrane-spanning G protein-coupled receptors. Both the ability of the …

Chemokines are chemotactic cytokines that mediate immune cell chemotaxis and lymphoid
tissue development. Recent advances have indicated that chemokines and their cognate …

The importance of chemokines and their receptors during infection, which initially had been
inferred from their ability to induce leukocyte chemotaxis in vitro, has now been firmly …

Chemokines are a family of low-molecular weight proteins that mediate their effects through
binding with chemokine receptors (a group of seven trans-membrane spanning G-protein …

Simple Summary For the last decade, the most successful approach for treating cancer has
been the use of monoclonal antibodies to immune checkpoint inhibitors (ICI), also known as …

Introduction 3. Structure and Function of Chemokines and Chemokine Receptors 3.1.
Chemokines affect the magnitude of the immune responses 3.2. Local chemokine …

Chemokines represent a family of over 40 small proteins that, for the most part, are secreted
into the environment and function by binding to G protein-coupled receptors (GPCRs) that …