Purpose: Lung cancer, the leading cause of cancer mortality worldwide, is often diagnosed
at late stages and responds poorly to conventional therapies, including chemotherapy and …

PUMA (p53 upregulated modulator of apoptosis) is a Bcl-2 homology 3 (BH3)-only Bcl-2
family member and a critical mediator of p53-dependent and-independent apoptosis …

Head and neck squamous cell carcinoma (HNSCC) ranks the eighth most common cancer
worldwide. The patients often present with advanced disease, which responds poorly to …

Replacement of the p53 tumor suppressor gene is a rational approach to the management
of malignant gliomas because p53 is frequently mutated or inactivated in these cancers …

Esophageal cancer is one of the most lethal human tumors, characterized by relative
chemoresistance and poor prognosis. Researchers have been seeking for multimodality to …

PURPOSE/OBJECTIVE.: To investigate whether exogenous PUMA expression suppresses
the growth of drug-resistant choriocarcinoma cells and sensitizes them to chemotherapeutic …

Genetic alterations of p53, which monitors DNA damage and operates cellular checkpoints,
is a major factor in the development of many types of cancer in human. PUMA, a direct …

Defective apoptosis contributes to tumorigenesis, although the critical molecular targets
remain to be fully characterized. PUMA, a BH3-only protein essential for p53-dependent …

Through global profiling of genes that were expressed soon after p53 expression, we
identified a novel gene termed PUMA (p53 upregulated modulator of apoptosis). The protein …

Although several genes that might mediate p53-induced apoptosis have been proposed,
none have previously been shown to play an essential role in this process through a …