Angiogenic sprouting is a complex, multi-step process involving highly integrated cell
behaviours, initial interaction with the environment and signalling pathways. Endothelial …

Revascularization of transplanted pancreatic islets is critical for survival and treatment of
type 1 diabetes. Questions concerning how islets influence local microvascular networks …

Blood vessel endothelium has been recently shown to induce endocrine pancreatic
development [1]. Because pancreatic endocrine cells or islets express high levels of …

Islet transplantation has become a widely accepted therapeutic option for selected patients
with type 1 diabetes mellitus. However, in order to achieve insulin independence a great …

Pancreatic islets implanted heterotopically (ie, into the kidney, spleen, or liver) become
poorly revascularized following transplantation. We hypothesized that islets implanted into …

Background. Blood flow is impaired in islet transplants, but there is conflicting evidence on
improving the outcome by promoting vascularization. We previously reported that islet …

Abstract Background/Aims: An important reason for the large amount of islets required for
successful islet transplantation is likely to be inadequate engraftment of the transplanted …

The mechanisms underlying early islet graft failure are not entirely clear, but are thought to
involve ischemic injury due to delayed vascularization. We hypothesize that blood vessels …

Successful islet transplantation depends on the infusion of sufficiently large quantities of
islets, requiring multiple pancreas donors per recipient. Unfortunately, more than 70% of …

The intra-islet microvasculature is a critical interface between the blood and islet endocrine
cells governing a number of cellular and pathophysiological processes associated with the …