Diosgenin ameliorates non-alcoholic fatty liver disease by modulating the gut microbiota and related lipid/amino acid metabolism in high fat diet-fed rats

Y Zhou, R Li, Y Zheng, M Song, S Zhang… - Frontiers in …, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease closely associated with
dietary habits. Diosgenin is abundant in yam, a common food and traditional Chinese …

Potent effects of dioscin against obesity in mice

M Liu, L Xu, L Yin, Y Qi, Y Xu, X Han, Y Zhao, H Sun… - Scientific Reports, 2015 - nature.com
The mechanisms of the natural product dioscin against non-alcoholic fatty liver disease
(NAFLD) are unclear. Thus, the purpose of the present study was to further confirm its effects …

Gentiopicroside improves high-fat diet-induced NAFLD in association with modulation of host serum metabolome and gut microbiome in mice

L Wang, Y Jiang, Q Yu, C Xiao, J Sun… - Frontiers in …, 2023 - frontiersin.org
Objective The incidence of non-alcoholic fatty liver disease is increasing every year, and
there is growing evidence that metabolites and intestinal bacteria play a causal role in …

[HTML][HTML] Diosgenin alleviates nonalcoholic steatohepatitis through affecting liver-gut circulation

M Yan, S Man, Y Liang, L Ma, L Guo, L Huang… - Pharmacological …, 2023 - Elsevier
Nonalcoholic steatohepatitis (NASH), as the aggressive form of nonalcoholic fatty liver
disease (NAFLD), rapidly becomes the leading cause of end-stage liver disease or liver …

Diosgenin ameliorates palmitic acid-induced lipid accumulation via AMPK/ACC/CPT-1A and SREBP-1c/FAS signaling pathways in LO2 cells

K Fang, F Wu, G Chen, H Dong, J Li, Y Zhao… - … and Alternative Medicine, 2019 - Springer
Background Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver
disease and is characterized by excessive hepatic lipid accumulation. Many studies have …

Dioscin alleviates non-alcoholic fatty liver disease through adjusting lipid metabolism via SIRT1/AMPK signaling pathway

H Yao, X Tao, L Xu, Y Qi, L Yin, XU Han, Y Xu… - Pharmacological …, 2018 - Elsevier
Dioscin, one natural product, has active effect against non-alcoholic fatty liver disease
(NAFLD) in our previous work. However, the pharmacological data are insufficient and the …

Diosgenin ameliorated type II diabetes-associated nonalcoholic fatty liver disease through inhibiting de novo lipogenesis and improving fatty acid oxidation and …

Y Zhong, Z Li, R Jin, Y Yao, S He, M Lei, X Wang, C Shi… - Nutrients, 2022 - mdpi.com
Diosgenin (DIO) is a dietary and phytochemical steroidal saponin representing multiple
activities. The present study investigated the protective effect of DIO on type II diabetes …

Diosgenin as a substitute for cholesterol alleviates NAFLD by affecting CYP7A1 and NPC1L1-related pathway

M Yan, Y Zhao, S Man, Y Dai, L Ma, W Gao - Phytomedicine, 2024 - Elsevier
Background Nonalcoholic fatty liver disease (NAFLD) rapidly becomes the leading cause of
end-stage liver disease or liver transplantation. Nowadays, there has no approved drug for …

Diammonium glycyrrhizinate protects against nonalcoholic fatty liver disease in mice through modulation of gut microbiota and restoration of intestinal barrier

Y Li, T Liu, C Yan, R Xie, Z Guo, S Wang… - Molecular …, 2018 - ACS Publications
Nonalcoholic fatty liver disease (NAFLD), as a common chronic liver disorder, is prevalent in
the world. Recent evidence demonstrates that the “gut–liver axis” is related well to the …

Nobiletin ameliorates nonalcoholic fatty liver disease by regulating gut microbiota and myristoleic acid metabolism

SZ Li, NN Zhang, X Yang, TQ Huang… - Journal of Agricultural …, 2023 - ACS Publications
Disturbance of the gut microbiota plays a critical role in the development of nonalcoholic
fatty liver disease (NAFLD). Increasing evidence supports that natural products may serve as …