Mature B lymphocytes are crucial components of adaptive immunity, a system essential for
the evolutionary fitness of mammals. Adaptive lymphocyte function requires an initially naïve …

The humoral immune response requires coordination of molecular programs to mediate
differentiation into unique B cell subsets that help clear the infection and form immune …

Molecular mechanisms underlying terminal differentiation of B cells into plasma cells are
major determinants of adaptive immunity but remain only partially understood. Here we …

Highlights•Multiple intrinsic and extrinsic inputs control B cell terminal differentiation.•
Differentiation is associated with loss of CpG methylation at promoters/enhancers.•Ezh2 …

B cell development is a multistep process that is tightly regulated at the transcriptional level.
In recent years, investigators have shed light on the transcription factor networks involved in …

The generation, development, maturation and selection of mammalian B lymphocytes is a
complex process that is initiated in the embryo and proceeds throughout life to provide the …

B‐cell development is a multistep process sustained by a highly coordinated transcriptional
network under the control of a limited set of transcription factors. Epigenetic mechanisms …

The mature naïve B cell repertoire consists of three well-defined populations: B1, B2
(follicular B, FOB), and marginal zone B (MZB) cells. FOB cells are the dominant mature B …

B lymphocytes are generally recognized as the essential component of humoral immunity
and also a regulator of innate immunity. The development of B cells is precisely regulated by …

The progression of hematopoietic stem cells (HSCs) to the B lymphocyte lineage requires
that uncommitted progenitors successfully negotiate the transition from multipotency to …