The molecular regulation of apoptosis and implications for radiation oncology

K R. BLANK, MS RUDOLTZ, GD KAO, RJ … - … journal of radiation …, 1997 - Taylor & Francis
One of the major goals of cancer research is to identify and understand the causes of
cellular proliferation. The role of cell death, or lack thereof, in carcinogenesis, tumour growth …

Biological adaptations of tumor cells to radiation therapy

A Carlos-Reyes, MA Muñiz-Lino… - Frontiers in …, 2021 - frontiersin.org
Radiation therapy has been used worldwide for many decades as a therapeutic regimen for
the treatment of different types of cancer. Just over 50% of cancer patients are treated with …

Apoptosis induction and tumor cell repopulation: the yin and yang of radiotherapy

K Lauber, LE Munoz, C Berens, V Jendrossek… - Radiation …, 2011 - Springer
The induction of tumor cell death is a central goal of radiotherapy. Surprisingly, a recent
study sheds new light on this process, and the results presented by Huang et al. strongly …

Association between radiation-induced cell death and clinically relevant radioresistance

Y Kuwahara, K Tomita, Y Urushihara, T Sato… - Histochemistry and cell …, 2018 - Springer
Radiotherapy (RT) is one of the major modalities for the treatment of human cancer and has
been established as an excellent local treatment for malignant tumors. However, the …

Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research

X Tong, R Tang, M Xiao, J Xu, W Wang… - Journal of hematology & …, 2022 - Springer
Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …

Regulated necrotic cell death in alternative tumor therapeutic strategies

Y Woo, HJ Lee, YM Jung, YJ Jung - Cells, 2020 - mdpi.com
The treatment of tumors requires the induction of cell death. Radiotherapy, chemotherapy,
and immunotherapy are administered to kill cancer cells; however, some cancer cells are …

Radiation induces apoptosis primarily through the intrinsic pathway in mammalian cells

X Cao, P Wen, Y Fu, Y Gao, X Qi, B Chen, Y Tao, L Wu… - Cellular …, 2019 - Elsevier
Radiation-induced tumor cells death is the theoretical basis of tumor radiotherapy. Death
signaling disorder is the most important factor for radioresistance. However, the signaling …

The role of apoptosis in radiation oncology

RE Meyn, L Milas, KK Ang - International journal of radiation …, 2009 - Taylor & Francis
Purpose: Apoptosis, as a mode of cell death in irradiated cell populations, has been the
subject of literarily hundreds if not thousands of published reports over the past few years …

The paradox role of caspase cascade in ionizing radiation therapy

N Rahmanian, SJ Hosseinimehr, A Khalaj - Journal of biomedical science, 2016 - Springer
Radiotherapy alone or in combination with chemotherapy/surgery is widely used for
treatment of cancers. It reduces tumor growth and prevents metastasis. While ionizing …

Cooperation effects of radiation and ferroptosis on tumor suppression and radiation injury

J Su, C Bian, Z Zheng, H Wang, L Meng… - Frontiers in Cell and …, 2022 - frontiersin.org
Ferroptosis is a kind of oxidative stress-dependent cell death characterized by iron
accumulation and lipid peroxidation. It can work in conjunction with radiation to increase …