Aims/hypothesis Delivery of the gene for human vascular endothelial growth factor (VEGF,
also known as VEGFA) to both the transplanted islets and the surrounding tissue may …

Aims/hypothesis The initial avascular period following islet transplantation seriously
compromises graft function and survival. Enhancing graft revascularisation to improve …

AIM: To determine whether the elevated vascular endothelial growth factor (VEGF)
expression produced by the transfected vascular endothelial cells (VECs) could stimulate …

Purpose. Islet transplantation is limited by islet graft failure because of poor
revascularization, host immune rejection, and nonspecific inflammatory response. Human …

For gene transfer strategies to improve islet engraftment, vascular endothelial growth factor
(VEGF) expression should be regulated in a way that matches the transient nature of …

Hypoxic damage is one of the major causes of islet graft failure and VEGF is known to play a
crucial role in revascularization. To address the effectiveness of a cationic lipid reagent as a …

OBJECTIVE: To investigate the possibility of improving the delivery of vascular endothelial
growth factor (VEGF) gene to the myocardium in rats by using ultrasound-mediated …

Ex vivo gene therapy approaches can improve the outcome of islet transplantation for
treating type I diabetes. We have recently shown improvement in islet survival and function …

Successful islet transplantation depends on the infusion of sufficiently large quantities of
islets, of which only∼ 30% become stably engrafted. Rapid and adequate revascularization …

Islet transplantation is limited by islet graft failure due to poor revascularization, host immune
rejection and nonspecific inflammatory response. Delivery of human vascular endothelial …