Background The prolonged β-lactam infusion strategy has emerged as the standard
treatment for sepsis or septic shock despite its unknown efficacy. This study aimed to assess …

Background The prolonged β-lactam antibiotics infusion has been an attractive strategy in
severe infections, because it provides a more stable free drug concentration and a longer …

Importance There is uncertainty about whether prolonged infusions of β-lactam antibiotics
improve clinically important outcomes in critically ill adults with sepsis or septic shock …

Importance Whether β-lactam antibiotics administered by continuous compared with
intermittent infusion reduces the risk of death in patients with sepsis is uncertain. Objective …

Background and rationale: β-Lactam antibiotics display a time-dependent mechanism of
action, with evidence suggesting improved outcomes when administering these drugs via …

Rationale: Optimization of β-lactam antibiotic dosing for critically ill patients is an intervention
that may improve outcomes in severe sepsis. Objectives: In this individual patient data meta …

Rationale: Continuous infusion of β-lactam antibiotics may improve outcomes because of
time-dependent antibacterial activity compared with intermittent dosing. Objectives: To …

The clinical advantages of prolonged (extended/continuous) infusion remain controversial.
Previous studies and reviews have failed to show consistent clinical benefits of extending …

Purpose This study aims to determine if continuous infusion (CI) is associated with better
clinical and pharmacokinetic/pharmacodynamic (PK/PD) outcomes compared to intermittent …

Background and rationale: Beta-lactam antibiotics are largely administered by bolus dosing,
despite displaying time-dependent pharmacokinetics and pharmacodynamics and there …