Infantile spasms is an epileptic encephalopathy of early infancy with specific clinical and
electroencephalographic (EEG) features, limited treatment options, and a poor prognosis …

Opinion statement Infantile spasms (IS) represent a major therapeutic challenge, as
cessation of spasms and normalization of the electroencephalogram (elimination of …

Abstract Background and Rationale: Infantile spasms (IS) are an age-specific seizure
disorder occurring in 1: 2,000 infants and associated with mental retardation in∼ 90% of …

Adrenocorticotropic hormone (ACTH) and corticosteroids are the usual first-line treatment
options for infantile spasms. Despite significant differences, these agents are often lumped …

Adrenocorticotrophic hormone (ACTH), oral corticosteroids and vigabatrin are now first-line
treatments for infantile spasms in the US and Europe. There is now increased knowledge …

Objective The limitations of adrenocorticotrophic hormone (ACTH) treatment for infantile
spasms (ISs), such as high costs, limited availability, and adverse effects (AEs), make it …

The ideal treatment of infantile spasms is unclear, but many studies advocate hormonal
treatment. In the United States, intramuscular ACTH is most widely used, despite the …

Introduction Infantile spasm (IS) is an epileptic syndrome with typical onset within the first 2
years of life. This condition might be caused by several etiologies. IS is associated with …

Although adrenocorticotropic hormone is the most commonly used treatment for infantile
spasms in the United States, the optimal regimen for this indication is not known. The …

Infantile spasms are a seizure disorder in young infants with diverse etiologies, suggesting
that they arise from any disturbance of central nervous system function during susceptible …