SARS-CoV-2 depends on host proteins for successful replication. In this issue, Williams et
al.(2023. J. Cell Biol. https://doi. org/10.1083/jcb. 202203060) report that the ER membrane …

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the etiologic agent for the
global COVID-19 pandemic, triggers the formation of endoplasmic reticulum (ER)-derived …

Positive-strand RNA viruses subvert the cellular endomembrane system for the generation
of distinct compartments termed replication organelles (ROs) that harbor the site where viral …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), like other coronaviruses,
replicates their genome in virus-induced cytosolic membrane-bound replication organelles …

Abstract SARS-CoV-2, like other coronaviruses, builds a membrane-bound replication
organelle to enable RNA replication. The SARS-CoV-2 replication organelle is composed of …

Coronavirus replication is associated with the remodeling of cellular membranes resulting in
the formation of double-membrane vesicles (DMVs). Recently, a pore spanning DMV was …

The SARS-CoV-2 viral infection transforms host cells and produces special organelles in
many ways, and we focus on the replication organelles, the sites of replication of viral …

The persistence of the coronavirus disease 2019 (COVID-19) pandemic has resulted in
increasingly disruptive impacts, and it has become the most devastating challenge to global …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-stranded RNA
virus that sits at the centre of the recent global pandemic. As a member of the coronaviridae …

Understanding the process of replication and transcription of SARS-CoV-2 is essential for
antiviral strategy development. The replicase polyprotein is indispensable for viral …