UNC93B1 attenuates the cGAS–STING signaling pathway by targeting STING for autophagy–lysosome degradation
H Zhu, R Zhang, L Yi, YD Tang… - Journal of Medical …, 2022 - Wiley Online Library
Stimulator of interferon genes (STING) is a pivotal innate immune adaptor, and its functions
during DNA virus infections have been extensively documented. However, its homeostatic …
during DNA virus infections have been extensively documented. However, its homeostatic …
UXT attenuates the CGAS-STING1 signaling by targeting STING1 for autophagic degradation
M Pan, Y Yin, T Hu, X Wang, T Jia, J Sun, Q Wang… - Autophagy, 2023 - Taylor & Francis
ABSTRACT STING1 (stimulator of interferon response cGAMP interactor 1), the pivotal
adaptor protein of CGAS (cyclic GMP-AMP synthase)-STING1 signaling, is critical for type I …
adaptor protein of CGAS (cyclic GMP-AMP synthase)-STING1 signaling, is critical for type I …
STING directly activates autophagy to tune the innate immune response
STING (stimulator of interferon genes) is a central molecule that binds to cyclic dinucleotides
produced by the cyclic GMP-AMP synthase (cGAS) to activate innate immunity against …
produced by the cyclic GMP-AMP synthase (cGAS) to activate innate immunity against …
Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases
P Hou, Y Lin, Z Li, R Lu, Y Wang, T Tian, P Jia… - Cellular & Molecular …, 2021 - nature.com
DNA sensing and timely activation of interferon (IFN)-mediated innate immunity are crucial
for the defense against DNA virus infections and the clearance of abnormal cells. However …
for the defense against DNA virus infections and the clearance of abnormal cells. However …
CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling
M Pan, T Hu, J Lyu, Y Yin, J Sun, Q Wang, L Xu, H Hu… - Autophagy, 2024 - Taylor & Francis
ABSTRACT STING1 (stimulator of interferon response cGAMP interactor 1) is the
quintessential protein in the CGAS-STING1 signaling pathway, crucial for the induction of …
quintessential protein in the CGAS-STING1 signaling pathway, crucial for the induction of …
[HTML][HTML] The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING
Stimulator of interferon genes (STING, also known as MITA, ERIS, or MPYS) is essential for
host immune responses triggered by microbial DNAs. However, the regulatory mechanisms …
host immune responses triggered by microbial DNAs. However, the regulatory mechanisms …
[HTML][HTML] STING guides the STX17-SNAP29-VAMP8 complex assembly to control autophagy
X Song, Y Xi, M Dai, T Li, S Du, Y Zhu, M Li, Y Li, S Liu… - Cell Insight, 2024 - Elsevier
The stimulator of interferon genes (STING) plays a pivotal role in orchestrating innate
immunity, and dysregulated activity of STING has been implicated in the pathogenesis of …
immunity, and dysregulated activity of STING has been implicated in the pathogenesis of …
[HTML][HTML] TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion
W Zheng, Z Zhou, Y Rui, R Ye, F Xia, F Guo… - … and Targeted Therapy, 2023 - nature.com
Innate immunity represents one of the main host responses to viral infection.,–STING
(Stimulator of interferon genes), a crucial immune adapter functioning in host cells, mediates …
(Stimulator of interferon genes), a crucial immune adapter functioning in host cells, mediates …
p38 inhibition provides anti–DNA virus immunity by regulation of USP21 phosphorylation and STING activation
Y Chen, L Wang, J Jin, Y Luan, C Chen, Y Li… - Journal of Experimental …, 2017 - rupress.org
Stimulator of IFN genes (STING) is a central adaptor protein that mediates the innate
immune responses to DNA virus infection. Although ubiquitination is essential for STING …
immune responses to DNA virus infection. Although ubiquitination is essential for STING …
[HTML][HTML] Human cytomegalovirus IE2 86 kDa protein induces STING degradation and inhibits cGAMP-mediated IFN-β induction
JE Kim, YE Kim, MF Stinski, JH Ahn… - Frontiers in microbiology, 2017 - frontiersin.org
Stimulator of interferon genes (STING) is a critical signaling molecule in the innate immune
response against DNA viruses by either directly sensing intracellular DNA or functioning as …
response against DNA viruses by either directly sensing intracellular DNA or functioning as …