UNC93B1 attenuates the cGAS–STING signaling pathway by targeting STING for autophagy–lysosome degradation

H Zhu, R Zhang, L Yi, YD Tang… - Journal of Medical …, 2022 - Wiley Online Library
Stimulator of interferon genes (STING) is a pivotal innate immune adaptor, and its functions
during DNA virus infections have been extensively documented. However, its homeostatic …

UXT attenuates the CGAS-STING1 signaling by targeting STING1 for autophagic degradation

M Pan, Y Yin, T Hu, X Wang, T Jia, J Sun, Q Wang… - Autophagy, 2023 - Taylor & Francis
ABSTRACT STING1 (stimulator of interferon response cGAMP interactor 1), the pivotal
adaptor protein of CGAS (cyclic GMP-AMP synthase)-STING1 signaling, is critical for type I …

STING directly activates autophagy to tune the innate immune response

D Liu, H Wu, C Wang, Y Li, H Tian, S Siraj… - Cell Death & …, 2019 - nature.com
STING (stimulator of interferon genes) is a central molecule that binds to cyclic dinucleotides
produced by the cyclic GMP-AMP synthase (cGAS) to activate innate immunity against …

Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases

P Hou, Y Lin, Z Li, R Lu, Y Wang, T Tian, P Jia… - Cellular & Molecular …, 2021 - nature.com
DNA sensing and timely activation of interferon (IFN)-mediated innate immunity are crucial
for the defense against DNA virus infections and the clearance of abnormal cells. However …

CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling

M Pan, T Hu, J Lyu, Y Yin, J Sun, Q Wang, L Xu, H Hu… - Autophagy, 2024 - Taylor & Francis
ABSTRACT STING1 (stimulator of interferon response cGAMP interactor 1) is the
quintessential protein in the CGAS-STING1 signaling pathway, crucial for the induction of …

[HTML][HTML] The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING

Q Wang, X Liu, Y Cui, Y Tang, W Chen, S Li, H Yu… - Immunity, 2014 - cell.com
Stimulator of interferon genes (STING, also known as MITA, ERIS, or MPYS) is essential for
host immune responses triggered by microbial DNAs. However, the regulatory mechanisms …

[HTML][HTML] STING guides the STX17-SNAP29-VAMP8 complex assembly to control autophagy

X Song, Y Xi, M Dai, T Li, S Du, Y Zhu, M Li, Y Li, S Liu… - Cell Insight, 2024 - Elsevier
The stimulator of interferon genes (STING) plays a pivotal role in orchestrating innate
immunity, and dysregulated activity of STING has been implicated in the pathogenesis of …

[HTML][HTML] TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion

W Zheng, Z Zhou, Y Rui, R Ye, F Xia, F Guo… - … and Targeted Therapy, 2023 - nature.com
Innate immunity represents one of the main host responses to viral infection.,–STING
(Stimulator of interferon genes), a crucial immune adapter functioning in host cells, mediates …

p38 inhibition provides anti–DNA virus immunity by regulation of USP21 phosphorylation and STING activation

Y Chen, L Wang, J Jin, Y Luan, C Chen, Y Li… - Journal of Experimental …, 2017 - rupress.org
Stimulator of IFN genes (STING) is a central adaptor protein that mediates the innate
immune responses to DNA virus infection. Although ubiquitination is essential for STING …

[HTML][HTML] Human cytomegalovirus IE2 86 kDa protein induces STING degradation and inhibits cGAMP-mediated IFN-β induction

JE Kim, YE Kim, MF Stinski, JH Ahn… - Frontiers in microbiology, 2017 - frontiersin.org
Stimulator of interferon genes (STING) is a critical signaling molecule in the innate immune
response against DNA viruses by either directly sensing intracellular DNA or functioning as …