Negative regulation of immune pathways is essential to achieve resolution of immune
responses and to avoid excess inflammation. DNA stimulates type I IFN expression through …

STING is an endoplasmic reticulum-resident protein regulating innate immunity. After
binding with cyclic guanosine monophosphate-AMP (cGAMP), STING translocates from the …

Abstract The Stimulator of Interferon Genes (STING) pathway initiates potent immune
responses upon recognition of DNA. To initiate signaling, serine 365 (S365) in the C …

Cytosolic DNA species derived from invading microbes or leaked from the nuclear or
mitochondrial compartments of the cell can trigger the induction of host defense genes by …

Stimulator of interferon genes (STING, also known as MITA, ERIS or MPYS) induces the
activation of TBK1 kinase and IRF3 transcription factor, upon sensing of microbial DNAs …

The innate immune DNA-sensing cyclic GMP-AMP synthase (cGAS)-stimulator of interferon
(IFN) gene (STING) pathway exerts strong antiviral activity through downstream IFN …

African swine fever is one of the most serious viral diseases that affects domestic and wild
pigs. The causative agent, African swine fever virus (ASFV), has evolved sophisticated …

MITA (also called STING) is a central adaptor protein in innate immune response to cytosolic
DNA. Cellular trafficking of MITA from the ER to perinuclear microsomes after DNA virus …

Iridoviruses are large DNA viruses which cause great economic losses to the aquaculture
industry and serious threats to ecological diversity worldwide. Singapore grouper iridovirus …

Stimulator of interferon genes (STING) is an endoplasmic reticulum–resident membrane
protein that mediates cytosolic pathogen DNA–induced innate immunity and inflammatory …