Autophagy induced by STING, an unnoticed and primordial function of cGAS
J Yang, X Tang, KS Nandakumar… - Cellular & Molecular …, 2019 - nature.com
Cyclic GMP-AMP synthase (cGAS), combined with dsDNA, produces cyclic GMP-AMP
(cGAMP) to stimulate STING and activates the kinases TBK1 and IKK to induce interferon …
(cGAMP) to stimulate STING and activates the kinases TBK1 and IKK to induce interferon …
TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination
Viral infection activates several transcription factors including NF-κB and IRF3, which
collaborate to induce type I interferons (IFNs) and innate antiviral response. MITA (also …
collaborate to induce type I interferons (IFNs) and innate antiviral response. MITA (also …
The mechanism of STING autoinhibition and activation
S Liu, B Yang, Y Hou, K Cui, X Yang, X Li, L Chen… - Molecular Cell, 2023 - cell.com
Summary 2′, 3′-cGAMP, produced by the DNA sensor cGAS, activates stimulator of
interferon genes (STING) and triggers immune response during infection. Tremendous effort …
interferon genes (STING) and triggers immune response during infection. Tremendous effort …
[PDF][PDF] Hepatitis C virus NS4B protein targets STING and abrogates RIG‐I–mediated type I interferon‐dependent innate immunity
S Nitta, N Sakamoto, M Nakagawa, S Kakinuma… - …, 2013 - Wiley Online Library
Hepatitis C virus (HCV) infection blocks cellular interferon (IFN)‐mediated antiviral signaling
through cleavage of Cardif by HCV‐NS3/4A serine protease. Like NS3/4A, NS4B protein …
through cleavage of Cardif by HCV‐NS3/4A serine protease. Like NS3/4A, NS4B protein …
A synthetic STING agonist inhibits the replication of human parainfluenza virus 3 and rhinovirus 16 through distinct mechanisms
Stimulator of interferon genes (STING), as a signaling hub in innate immunity, plays a central
role for the effective initiation of host defense mechanisms against microbial infections. Upon …
role for the effective initiation of host defense mechanisms against microbial infections. Upon …
ER: a critical hub for STING signaling regulation
Abstract The Stimulator of Interferon Genes (STING) has a crucial role in mediating the
immune response against cytosolic double-stranded DNA (dsDNA) and its activation is …
immune response against cytosolic double-stranded DNA (dsDNA) and its activation is …
A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology
T Prabakaran, A Troldborg, S Kumpunya, I Alee… - …, 2021 - thelancet.com
Background Nucleic acids are potent stimulators of type I interferon (IFN-I) and antiviral
defense, but may also promote pathological inflammation. A range of diseases are …
defense, but may also promote pathological inflammation. A range of diseases are …
[HTML][HTML] STING1 in sepsis: Mechanisms, functions, and implications
Sepsis is a life-threatening clinical syndrome and one of the most challenging health
problems in the world. Pathologically, sepsis and septic shock are caused by a dysregulated …
problems in the world. Pathologically, sepsis and septic shock are caused by a dysregulated …
[HTML][HTML] African swine fever virus MGF-505-7R negatively regulates cGAS–STING-mediated signaling pathway
D Li, W Yang, L Li, P Li, Z Ma, J Zhang, X Qi… - The Journal of …, 2021 - journals.aai.org
African swine fever virus (ASFV) is a devastating infectious disease in pigs, severely
threatening the global pig industry. To efficiently infect animals, ASFV must evade or inhibit …
threatening the global pig industry. To efficiently infect animals, ASFV must evade or inhibit …
STING operation at the ER/Golgi interface
DNA is present in the nucleus and mitochondria of eukaryotic cells. There are, however,
certain instances in which DNA emerges in the cytosol. The two major sources of cytosolic …
certain instances in which DNA emerges in the cytosol. The two major sources of cytosolic …