Pro-inflammatory and pathogenic properties of Annexin-A1: the whole is greater than the sum of its parts

F D'Acquisto, G Piras, L Rattazzi - Biochemical pharmacology, 2013 - Elsevier
According to Aristotle,“The whole is greater than the sum of its parts” and yet, although a
long time has passed still, we seem to struggle to accept this universal concept. Searching in …

Identification of novel binding partners (annexins) for the cell death signal phosphatidylserine and definition of their recognition motif

S Rosenbaum, S Kreft, J Etich, C Frie… - Journal of Biological …, 2011 - ASBMB
Identification and clearance of apoptotic cells prevents the release of harmful cell contents
thereby suppressing inflammation and autoimmune reactions. Highly conserved annexins …

[HTML][HTML] Annexin II binds to the membrane of A549 cells in a calcium-dependent and calcium-independent manner

L Liu, JQ Tao, UJP Zimmerman - Cellular signalling, 1997 - Elsevier
We investigated the nature of annexin II binding to the biological membranes using a lung
epithelium-derived cell line A549. The cytosolic and membrane fractions of A549 cells were …

Annexin A2 is a soluble mediator of macrophage activation

JFA Swisher, U Khatri… - Journal of Leucocyte …, 2007 - academic.oup.com
On the surface of the macrophage, annexin A2 tetramer (A2t) serves as a docking protein or
recognition element for bacterial and viral pathogens. Plasma levels of free A2t have been …

Cleavage of annexin A1 by ADAM10 during secondary necrosis generates a monocytic “find-me” signal

KE Blume, S Soeroes, H Keppeler… - The Journal of …, 2012 - journals.aai.org
Annexin A1 is an intracellular calcium/phospholipid-binding protein that is involved in
membrane organization and the regulation of the immune system. It has been attributed an …

[HTML][HTML] Calcium-dependent interaction of annexin I with annexin II and mapping of the interaction sites

KH Lee, DS Na, JW Kim - FEBS letters, 1999 - Elsevier
Annexins are multifunctional intracellular proteins with Ca2+-and phospholipid-binding
properties. Their structures consist of four conserved repeat domains that form the core and …

Participation of annexins in protein phosphorylation

B Rothhut - Cellular and Molecular Life Sciences CMLS, 1997 - Springer
Simultaneous discovery of members of the annexin family of calcium and phospholipid
binding proteins by several groups is intimately linked to the possibility that these proteins …

Annexin A2 tetramer activates human and murine macrophages through TLR4

JFA Swisher, N Burton, SM Bacot… - Blood, The Journal …, 2010 - ashpublications.org
Annexins are a large family of intracellular phospholipid-binding proteins, yet several
extracellular roles have been identified. Specifically, annexin A2, found in a heterotetrameric …

Function, expression and localization of annexin A7 in platelets and red blood cells: insights derived from an annexin A7 mutant mouse

C Herr, CS Clemen, G Lehnert, R Kutschkow… - BMC biochemistry, 2003 - Springer
Background Annexin A7 is a Ca 2+-and phospholipid-binding protein expressed as a 47
and 51 kDa isoform, which is thought to be involved in membrane fusion processes …

Annexin 1 localisation in tissue eosinophils as detected by electron microscopy

SM Oliani, AS Damazo, M Perretti - Mediators of Inflammation, 2002 - Wiley Online Library
Background: Human and rodent leukocytes express high levels of the glucocorticoid‐
inducible protein annexin 1 (ANXA1)(previously referred to as lipocortin 1). Neutrophils and …