Despite considerable efforts in research and clinical studies, stroke is still one of the leading
causes of death and disability worldwide. Originally, stroke was considered a vascular …

Stroke is one of the leading causes of death and disability worldwide. The long‐standing
dogma that stroke is exclusively a vascular disease has been questioned by extensive …

Immunity and inflammation are key elements of the pathobiology of stroke, a devastating
illness second only to cardiac ischemia as a cause of death worldwide. The immune system …

The immune system is rapidly activated after ischemic stroke. As immune cells migrate and
infiltrate across the blood-brain barrier into the ischemic region, a cascade of cellular and …

Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …

This issue of Neurotherapeutics focuses on immunologic changes after stroke, a promising
target for stroke therapies. Stroke is a deadly and disabling disease; globally, it kills 12% of …

The immune response to stroke is an exciting target for future stroke therapies. Stroke is a
leading cause of morbidity and mortality worldwide, and clot removal (mechanical or …

After ischemic stroke, the integrity of the blood-brain barrier is compromised. Peripheral
immune cells, including neutrophils, T cells, B cells, dendritic cells, and macrophages …

Approaches for the effective management of acute stroke are sparse, and many measures
for brain protection fail. However, our ability to modulate the immune system and modify the …

Acute ischemic stroke is the third leading cause of death in industrialized countries and the
most frequent cause of permanent disability in adults worldwide. Despite advances in the …