Atypical meiosis can be adaptive in outcrossed Schizosaccharomyces pombe due to wtf meiotic drivers

MA Bravo Núñez, IM Sabbarini, LE Eide, RL Unckless… - Elife, 2020 - elifesciences.org
Killer meiotic drivers are genetic parasites that destroy 'sibling'gametes lacking the driver
allele. The fitness costs of drive can lead to selection of unlinked suppressors. This …

Diverse mating phenotypes impact the spread of wtf meiotic drivers in Schizosaccharomyces pombe

JFL Hernández, RM Helston, JJ Lange, RB Billmyre… - Elife, 2021 - elifesciences.org
Meiotic drivers are genetic elements that break Mendel's law of segregation to be
transmitted into more than half of the offspring produced by a heterozygote. The success of a …

[HTML][HTML] A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver's antidote

MA Bravo Núñez, JJ Lange, SE Zanders - PLoS Genetics, 2018 - journals.plos.org
Meiotic drivers are selfish alleles that subvert gametogenesis to increase their transmission
into progeny. Drivers impose a fitness cost, putting pressure on the genome to evolve …

[HTML][HTML] Dramatically diverse Schizosaccharomyces pombe wtf meiotic drivers all display high gamete-killing efficiency

MA Bravo Núñez, IM Sabbarini, MT Eickbush… - PLoS …, 2020 - journals.plos.org
Meiotic drivers are selfish alleles that can force their transmission into more than 50% of the
viable gametes made by heterozygotes. Meiotic drivers are known to cause infertility in a …

[HTML][HTML] S. pombe wtf drivers use dual transcriptional regulation and selective protein exclusion from spores to cause meiotic drive

NL Nuckolls, A Nidamangala Srinivasa, AC Mok… - PLoS …, 2022 - journals.plos.org
Meiotic drivers bias gametogenesis to ensure their transmission into more than half the
offspring of a heterozygote. In Schizosaccharomyces pombe, wtf meiotic drivers destroy the …

wtf genes are prolific dual poison-antidote meiotic drivers

NL Nuckolls, MA Bravo Núñez, MT Eickbush… - Elife, 2017 - elifesciences.org
Meiotic drivers are selfish genes that bias their transmission into gametes, defying
Mendelian inheritance. Despite the significant impact of these genomic parasites on …

The wtf meiotic driver gene family has unexpectedly persisted for over 100 million years

M De Carvalho, GS Jia, AN Srinivasa, RB Billmyre… - Elife, 2022 - elifesciences.org
Meiotic drivers are selfish elements that bias their own transmission into more than half of
the viable progeny produced by a driver+/driver− heterozygote. Meiotic drivers are thought …

Killer Meiotic Drive and Dynamic Evolution of the wtf Gene Family

MT Eickbush, JM Young… - Molecular Biology and …, 2019 - academic.oup.com
Natural selection works best when the two alleles in a diploid organism are transmitted to
offspring at equal frequencies. Despite this, selfish loci known as meiotic drivers that bias …

Veni, vidi, vici: the success of wtf meiotic drivers in fission yeast

JF López Hernández, SE Zanders - Yeast, 2018 - Wiley Online Library
Meiotic drivers are selfish DNA loci that can bias their own transmission into gametes. Owing
to their transmission advantages, meiotic drivers can spread in populations even if the …

Genome rearrangements and pervasive meiotic drive cause hybrid infertility in fission yeast

SE Zanders, MT Eickbush, JS Yu, JW Kang, KR Fowler… - elife, 2014 - elifesciences.org
Hybrid sterility is one of the earliest postzygotic isolating mechanisms to evolve between two
recently diverged species. Here we identify causes underlying hybrid infertility of two …