[HTML][HTML] Sigma-1 receptor: a potential therapeutic target for traumatic brain injury
M Shi, F Chen, Z Chen, W Yang, S Yue… - Frontiers in cellular …, 2021 - frontiersin.org
The sigma-1 receptor (Sig-1R) is a chaperone receptor that primarily resides at the
mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) and acts as a …
mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) and acts as a …
[HTML][HTML] The involvement of the sigma-1 receptor in neurodegeneration and neurorestoration
K Ruscher, T Wieloch - Journal of pharmacological sciences, 2015 - Elsevier
Abstract The sigma-1 receptor (Sig-1R) is a single 25 kD polypeptide and a chaperone
protein immersed in lipid rafts of the endoplasmic reticulum (ER) where it interacts with …
protein immersed in lipid rafts of the endoplasmic reticulum (ER) where it interacts with …
Sigma-2 receptor as a potential therapeutic target for treating central nervous system disorders
K Terada, K Migita, Y Matsushima… - Neural regeneration …, 2019 - journals.lww.com
The sigma receptor (Sig-R) was first reported by Martin et al.(1976) and was initially
classified into the opioid receptor family. However, Sig-R was subsequently found to differ …
classified into the opioid receptor family. However, Sig-R was subsequently found to differ …
Sigma-1 receptors fine-tune the neuronal networks
SYA Tsai, TP Su - Sigma Receptors: Their Role in Disease and as …, 2017 - Springer
The endoplasmic reticular (ER) protein sigma-1 receptor (Sig-1R) has been implicated in
CNS disorders including but not limited to neurodegenerative diseases, depression …
CNS disorders including but not limited to neurodegenerative diseases, depression …
[HTML][HTML] The sigma-1 receptor in cellular stress signaling
T Hayashi - Frontiers in neuroscience, 2019 - frontiersin.org
After decades of research, the sigma-1 receptor (Sig-1R)'s structure, and molecular functions
are being unveiled. Sig-1R is an integral endoplasmic reticulum (ER) membrane protein …
are being unveiled. Sig-1R is an integral endoplasmic reticulum (ER) membrane protein …
[HTML][HTML] Sigma-1 receptor-modulated neuroinflammation in neurological diseases
J Jia, J Cheng, C Wang, X Zhen - Frontiers in cellular neuroscience, 2018 - frontiersin.org
A large body of evidence indicates that sigma-1 receptors (Sig-1R) are important drug
targets for a number of neuropsychiatric disorders. Sig-1Rs are enriched in central nervous …
targets for a number of neuropsychiatric disorders. Sig-1Rs are enriched in central nervous …
Role of sigma-1 receptor in cocaine abuse and neurodegenerative disease
Abstract Sigma-1 receptors (Sig-1R) are recognized as a unique class of non-G protein-
coupled intracellular protein. Sig-1R binds to its ligand such as cocaine, resulting in …
coupled intracellular protein. Sig-1R binds to its ligand such as cocaine, resulting in …
The sigma-1 receptor: roles in neuronal plasticity and disease
Sigma-1 receptors (Sig-1Rs) have been implicated in many neurological and psychiatric
conditions. Sig-1Rs are intracellular chaperones that reside specifically at the endoplasmic …
conditions. Sig-1Rs are intracellular chaperones that reside specifically at the endoplasmic …
Sigma-1 receptors and neurodegenerative diseases: towards a hypothesis of sigma-1 receptors as amplifiers of neurodegeneration and neuroprotection
Sigma-1 receptors are molecular chaperones that may act as pathological mediators and
targets for novel therapeutic applications in neurodegenerative diseases. Accumulating …
targets for novel therapeutic applications in neurodegenerative diseases. Accumulating …
Sigma-1 receptor and neuronal excitability
S Kourrich - Sigma proteins: evolution of the concept of sigma …, 2017 - Springer
Abstract The sigma-1 receptor (Sig-1R), via interaction with various proteins, including
voltage-gated and ligand-gated ion channels (VGICs and LGICs), is involved in a plethora of …
voltage-gated and ligand-gated ion channels (VGICs and LGICs), is involved in a plethora of …