DARPP-32 (PPP1R1B) was discovered as a substrate of cAMP-dependent protein kinase
(PKA) enriched in dopamine-innervated brain areas. It is one of three related, PKA-regulated …

Our current understanding of the relationship between the dopaminergic system and human
brain disorders is based on two fundamental discoveries: dopamine-replacement herapy …

In situ hybridization histochemistry was used to determine the laminar distribution of D1, D2,
D3, D4, and D5 dopamine receptor mRNAs in the primate prefrontal cortex and to compare …

In dopaminoceptive neurons, dopamine-and cAMP-regulated phosphoprotein of 32 kDa
(DARPP-32) plays a central role in integrating the effects of dopamine and other …

The Neurobiology of Dopamine Signaling Page 1 Bioscience Reports, Vol. 21, No. 3, June 2001
( 2001) NOBEL LECTURE DECEMBER 8, 2000 The Neurobiology of Dopamine Signaling …

Antibodies to the D1 dopamine receptor were used to localize this protein in several areas of
human and monkey cerebral cortex with light and electron microscopy. In addition to cell …

A cDNA clone is described that encodes a novel G-protein-coupled dopamine receptor
(DopR99B) expressed in Drosophila heads. The DopR99B receptor maps to 99B3–5, close …

The D3 dopamine (DA) receptor is a member of the D2-like DA receptor family. While the D2
receptor is abundant especially in motor-regions of the striatum, the D3 receptor shows a …

Using homologous recombination, we generated mice lacking phosphodiesterase-mediated
(PDE1B) cyclic nucleotide-hydrolyzing activity. PDE1B−/− mice showed exaggerated …

A polyclonal antibody was generated using synthetic peptides designed in a specific
sequence of the rat D3 receptor (D3R). Using transfected cells expressing recombinant …