Iron is a vitally important element in mammalian metabolism because of its unsurpassed
versatility as a biologic catalyst. However, when not appropriately shielded or when present …

Hereditary hemochromatosis is a common disorder of iron metabolism most frequently
associated with mutations in the HFE gene. Hereditary hemochromatosis may be caused by …

Hemochromatosis is a common disorder characterized by excess iron absorption and
accumulation of iron in tissues. Usually hemochromatosis is inherited in an autosomal …

Elucidation of the molecular pathways of iron transport through cells and its control is
leading to an understanding of genetic iron loading conditions. The general phenotype of …

Non-HFE hereditary haemochromatosis (HH) refers to a genetically heterogeneous group of
iron overload disorders that are unlinked to mutations in the HFE gene. The four main types …

Ferroportin1 in absorption of dietary iron (a) and release of iron stores (b).(a) Dietary
nonheme iron at the luminal surface of the villus enterocyte is reduced by ferric reductase …

The cellular iron exporter ferroportin 1 is expressed in both the duodenum and in cells of the
mononuclear phagocyte system. Expression of ferroportin 1 protein on the cell surface is …

The availability of molecular tools for studying HFE mutations has allowed investigators to
identify novel forms of non-HFE related genetic hemochromatosis (GH). Fifteen years ago …

Iron is a trace element that is vital for life. It is a component of innumerable hemoproteins
and many essential non-heme iron proteins that are involved in oxygen binding and …

Hereditary hemochromatosis, a very common genetic defect in the Caucasian population, is
characterized by progressive tissue iron overload which leads to irreversible organ damage …