Abstract Background and Objective Piperacillin/tazobactam is one of the most frequently
used antimicrobials in older adults. Using an opportunistic study design, we evaluated the …

OBJECTIVES: To characterize the population pharmacokinetics of metronidazole in preterm
neonates. PATIENTS AND METHODS: Data were collected prospectively from 32 preterm …

Objectives: We investigated the population pharmacokinetics and pharmacodynamics of
piperacillin and tazobactam in hospitalized patients. Patients and methods: A multicentre …

Objective: The population pharmacokinetics of amikacin, in neonates, was investigated
using the nonlinear mixed effects model (NONMEM). Methods: One hundred and six steady …

Background There is a lack of evidence on oral amoxicillin pharmacokinetics and exposure
in neonates with possible serious bacterial infection (pSBI). We aimed to describe …

The objective of this study was to evaluate the steady-state pharmacokinetics and
pharmacodynamics of piperacillin/tazobactam, administered by prolonged infusion, in …

Background Preterm neonates are usually not part of a traditional drug development
programme, however they are frequently administered medicines. Developing modelling …

Aim To make programs for population pharmacokinetic analysis and to assess the ability of
this method in pharmacokinetic parameter estimation and in the prediction of serum …

Abstract Background and Objective Piperacillin is a broad-spectrum β-lactam antibiotic
commonly prescribed in intensive care units. Many piperacillin population pharmacokinetic …

Objectives Knowledge on the tissue penetration of piperacillin-tazobactam in children with
sepsis is lacking. In this study, the feasibility and performance of microdialysis experiments …