MAP30 Inhibits Bladder Cancer Cell Migration and Invasion In Vitro Through Suppressing Akt Pathway and the Epithelial/Mesenchymal Transition Process

S Zhang, Z Shi, K Pang, H He, J Chen… - DNA and Cell …, 2020 - liebertpub.com
The antitumor activity of Momordica anti-human immunodeficiency virus protein of 30 kDa
(MAP30) has been proved. However, the role of MAP30 on tumor metastasis has not yet …

Antitumor mechanism of MAP30 in bladder cancer T24 cells, and its potential toxic effects in mice

Z Shi, K Pang, W Yang, J Zhou, B Dong… - Cellular and Molecular …, 2020 - cellmolbiol.org
To investigate the antitumor mechanism of MAP30 in human bladder cell line (T24) and its
potential toxic effects in mice. In this study, the biological behavior of MAP30's influence on …

MAP9 Exhibits Protumor Activities and Immune Escape toward Bladder Cancer by Mediating TGF‐β1 Pathway

C Zhang, B Han, Y Guo, H Guan, Z Chen… - Journal of …, 2022 - Wiley Online Library
To investigate more potential targets for the treatment of human bladder cancer, quantitative
reverse transcription polymerase chain reaction (qRT‐PCR) and high‐content screening …

MAP30 inhibits autophagy through enhancing acetyltransferase p300 and induces apoptosis in acute myeloid leukemia cells

S Qian, L Sun, J Li, J Wu, G Hu, Y Han… - Oncology …, 2016 - spandidos-publications.com
Momordica anti-human immunodeficiency virus protein of 30 kDa (MAP30) has been shown
to exhibit potent antitumor activities against several solid tumors. In the present investigation …

Phosphorylated MAPK14 promotes the proliferation and migration of bladder cancer cells by maintaining RUNX2 protein abundance

J Liu, X Yu, B Liu, H Yu, Z Li - Cancer Management and Research, 2020 - Taylor & Francis
Background Mitogen-activated protein kinase 14 (MAPK14) acts as an integration point for
multiple biochemical signal pathways. High expressions of MAPK14 have been found in a …

Expression of Momordica charantia MAP30 and its antitumor effect on bladder cancer cells.

H Hlin, Z Zhi-Guo, H Cong-Hui, Z Yan… - Minerva urologica e …, 2014 - europepmc.org
Background Momordica charantia (MC) is an edible medicinal plant that is known for its
diversified biological functions. Momordica Antiviral Protein 30kD (MAP30) is a type I single …

PP242 suppresses bladder cancer cell proliferation and migration through deactivating the mammalian target of rapamycin complex 2/AKT1 signaling pathway

Z Zhang, G Zhang, C Kong… - Molecular medicine …, 2016 - spandidos-publications.com
While most cancer types are resistant to mammalian target of rapamycin complex 1
(mTORC1) inhibitor rapamycin, recent studies have identified mTORC2 as an important …

[HTML][HTML] MAP30 protein from Momordica charantia is therapeutic and has synergic activity with cisplatin against ovarian cancer in vivo by altering metabolism and …

DW Chan, MMH Yung, YS Chan, Y Xuan… - Pharmacological …, 2020 - Elsevier
Increasing evidence shows that Traditional Chinese Medicine (TCM) has an obvious appeal
for cancer treatment, but there is still a lack of scientific investigation of its underlying …

SC66 inhibits the proliferation and induces apoptosis of human bladder cancer cells by targeting the AKT/β‐catenin pathway

W Chen, S Zhao, W Yu, T Rao, Y Ruan… - Journal of Cellular …, 2021 - Wiley Online Library
Bladder cancer (BC) is a major disease of the genitourinary tract, and chemotherapy is one
of the main treatments commonly used at present. SC66 is a new type of allosteric AKT …

Cloning, expression and functional analysis of MAP30 from Momordica charantia reveals its induction of apoptosis of the BGC-823 cells

XH Han, YJ Xue, DY Chen, SH Shao, H Huang… - African Journal of …, 2011 - ajol.info
Abstract Momordica Anti-HIV Protein 30 (MAP30) can induce many tumour cells apoptosis,
but the mechanism is still unclear. Since the content of MAP30 in Momordica charantia is …