To determine whether insulin regulation of lipolysis is abnormal in subjects with poorly
controlled insulin-dependent diabetes mellitus (IDDM), free-fatty acid flux ([1-14C] palmitate) …

Adipocyte glucose transport can be impaired by prolonged hyperglycemic conditions.
However, at the whole body level, lipolysis is quantitatively a more important function of …

To determine whether type 2 diabetes mellitus alters systemic and regional free fatty acid
([3H] palmitate) metabolism, 14 nondiabetic (ND) and 14 type 2 diabetic (D) subjects …

Studies were conducted to determine whether regional free fatty acid (FFA) release is
differentially regulated by insulin. Systemic, leg, and splanchnic palmitate rate of …

We tested the hypothesis that the previously observed association among
hypertriglyceridemia, hyperinsulinemia, and insulin resistance could be explained by a …

To elucidate potential mechanisms for insulin resistance occurring early in the development
of type 2 diabetes, we studied 10 young healthy individuals, each with two first-degree …

Fatty acids are important oxidative fuel for liver, kidney, skeletal muscle, and myocardium.
There has been much interest in the role of fatty acids in the pathogenesis of non-insulin …

The possible existence of regional differences in the antilipolytic action of insulin in human
adipose tissue was investigated in vitro. Insulin-induced inhibition of glycerol release and …

Adipose tissue is considered as the body's largest storage organ for energy in the form of
triglycerides, which are mobilised through the lipolysis process to provide fuel to other …

Suppression of hepatic glucose output (HGO) has been shown to be primarily mediated by
peripheral rather than portal insulin concentrations; however, the mechanism by which …