Introduction: The P2X7 receptor (P2X7R) has an important role in inflammation and
immunity, but until recently, clinical application has been limited by a lack of specific …

Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the
extracellular milieu, being massively released by stressed or dying cells. Once outside the …

The P2X7 receptor (P2X7R) is a nonselective cation channel that is activated by
extracellular ATP and triggers the secretion of several proinflammatory substances, such as …

Damage associated molecular patterns (DAMPs) are intracellular molecules released from
infected or injured cells to activate inflammatory and reparatory responses. One of the most …

The P2X7 receptor is an ATP-gated nonselective cation channel that has been linked to a
number of inflammatory diseases. Activation of the P2X7 receptor by elevated levels of ATP …

The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not
exclusively, on immune cells. P2X7 activation results in a number of downstream events …

The ATP-sensitive homomeric P2X7 receptor (P2X7R) has received particular attention as a
potential drug target because of its widespread involvement in inflammatory diseases as a …

ATP‐sensitive P2X7 receptors are localized on cells of immunological origin including
peripheral macrophages and glial cells in the CNS. Activation of P2X7 receptors leads to …

Background: The P2X7 receptor is present in a variety of cell types involved in pain,
inflammatory processes and neurodegenerative conditions, thus it may be an appealing …

Extracellular nucleotides are important mediators of activation, triggering various responses
through plasma membrane P2 and P1 receptors. P2 receptors are further subdivided into …