Patients with severe asthma have asthma symptoms which are difficult to control, require
high dosages of medication, and continue to experience persistent symptoms, asthma …

Assessment and management of asthma is complicated by the heterogeneous
pathophysiological mechanisms that underlie its clinical presentation, which are not …

Introduction: The development of monoclonal antibody-based biologics targeted at inhibition
of the Th2 cytokines IL-4, IL-5 and IL-13 represent potentially effective treatments for patients …

Biologics are emerging as a key component of severe asthma management. In patients with
T2-high severe asthma, the addition of treatments targeting immunoglobulin E and IL-5 to …

Guidelines for the management of severe asthma do not emphasize the measurement of the
inflammatory component of airway disease to indicate appropriate treatments or to monitor …

▪ Abstract When asthma is diagnosed, eosinophilic inflammation and airway remodeling are
established in the bronchial airways and can no longer be separated as cause and effect …

Asthma is a serious health and socioeconomic issue all over the world, affecting more than
300 million individuals. The disease is considered as an inflammatory disease in the airway …

Although human asthma is commonly regarded as an allergic disorder characterized by type
2 cytokine expression and eosinophilic inflammation in the airways, it is clearly …

Objectives To review current thinking regarding the role of personalized phenotype-driven
as opposed to broad guideline-based therapies in asthma and to speculate on the relative …

Asthma is a chronic disease with abnormal inflammatory and immunological responses. The
disease initiates by antigens in subjects with genetic susceptibility. However, environmental …