Antisense promised major advances in treating a broad range of intractable diseases, but in
recent years progress has been stymied by technical problems, most notably inadequate …

The concept of using antisense oligonucleotides to interfere with gene expression offers a
new therapeutic strategy for the treatment of diseases resulting from overexpression or …

Morpholino and phosphorothioate (S-DNA) antisense oligos were compared in both cell-
free and in-cell translation systems. In the most stringent test of specificity in the cell-free …

One of the many features that make morpholino oligos unique among the antisense
structural types is an uncharged backbone. While this feature eliminates the nonspecific …

Antisense technology constitutes development of sequence-specific DNA or RNA analogs
that can block the activity of selected single-stranded genetic sequences and offer the …

Modulation of gene expression using oligonucleotides (oligos) is currently an area of
intense activity, both from therapeutic, as well as research perspectives. To develop oligos …

RNase H-competent phosphorothioates (S-DNAs) have dominated the antisense field in
large part because they offer reasonable resistance to nucleases, they afford good efficacy …

We report a simple and effective means for delivering Morpholino antisense oligos into the
cytosol of cultured anchorage-dependent animal cells. This method, referred to as scrape …

Oligonucleotide therapeutics have the potential to become a third pillar of drug development
after small molecules and protein therapeutics. However, the three approved …

Antisense oligonucleotides provide a simple and efficient approach for developing target-
selective drugs because they can modulate gene expression sequence-specifically …