A NUMBER of laboratories have reported the isolation from eukaryotic cells of mRNAs
linked covalently at their 3′-OH termini to polyadenylic add (poly (A)) 1–4. The chain of …

THE discovery that messenger RNA (mRNA) in mammalian cells contains sequences of
polyadenylic acid (poly A) about 200 nucleotides long localized at the 3′-OH terminus of …

IT is commonly assumed that the messenger RNA (mRNA) of prokaryotes lacks the poly (A)
sequences which characterise the 3′ terminus of most mRNA of eukaryotes. A report of the …

IT has been established that many eukaryotic mRNAs contain poly (adenylic acid) tracts at
their 3′-termini. The polyadenylation of mRNA occurs post-transcriptionally in the nucleus …

Abstract POLYADENYLIC acid, poly (A), which was discovered some time ago in
mammalian cells1, 2, originates in the cell nucleus as part of HnRNA* and is also found in …

Abstract A single U→ G transversion in the 3′ consensus sequence AAUAAA of the
adenovirus early region 1A gene was constructed and the effect of this mutation on …

POLYNUCLEOTIDE sequences rich in adenylic acid (poly (A)) have been found in a variety
of eukaryotic messenger, heterogenous nuclear (Hn) and viral RNAs1–5. Poly (A) tracts in …

Publisher Summary This chapter discusses the enzymes that are likely to be responsible for
synthesis of poly (A) sequences and has led to new methods for obtaining preparations of …

To determine the role of poly (A) polymerase in 3′-end processing of mRNA, the effect of
purified poly (A) polymerase antibodies on endonucleolytic cleavage and polyadenylation …

MUCH interest has centred recently on the discoveries of ribohomopolymer sequences in
RNAs of eukaryotic cells. Poly (A) 1–3, poly (U) 4 and poly (G) 5 regions have been found in …