Objective To elucidate why diabetes is so difficult to treat despite the present tools and
pharmacologic armamentarium and to provide insights into emerging therapies by …

Recent successes in treating type 1 diabetic patients with islet transplantation portends a
future need for an increase in available islets. Ductal structures of the adult pancreas contain …

Islets of Langerhans are islands of endocrine cells scattered throughout the pancreas. A
number of new studies have pointed to the potential for conversion of non-β islet cells in to …

The islets of Langerhans are clusters of endocrine cells located within the pancreas. Insulin-
producing beta cells are the major cell type within islets, with glucagon-producing alpha …

Ductal structures of the adult pancreas contain stem cells that differentiate into islets of
Langerhans. Here, we grew pancreatic ductal epithelial cells isolated from prediabetic adult …

The overall conservation between mouse and human pancreatic development, islet
physiology and etiology of diabetes encourages the translation of novel β cell replacement …

The pancreas anatomy in all mammals, in which islets of Langerhans are scattered
throughout the parenchyma and comprise only 1–2% of the pancreas mass, makes it …

The islets of Langerhans play a major role in control of metabolic fuel homeostasis. The
rapid increase in incidence of diabetes worldwide has spurred renewed interest in islet cell …

The terms “islet” and “β‐cell” are often used interchangeably, yet islets are highly complex
multicellular organelles that contain the insulin‐producing β‐cells and four other cells types …

Almost 50 years ago, scientists developed the bi-hormonal abnormality hypothesis, stating
that diabetes is not caused merely by the impaired insulin signaling. Instead, the presence of …