The etiology of human inflammatory bowel diseases (IBDs) is believed to involve
inappropriate host responses to the complex commensal microbial flora in the gut, although …

The current paradigm of inflammatory bowel diseases (IBD), both Crohn's disease (CD) and
ulcerative colitis (UC), involves the interaction between environmental factors in the …

Intestinal mucosal barrier function is the capacity of the intestine to provide adequate
containment of luminal microorganisms and molecules while preserving the ability to absorb …

A critical function of the intestinal mucosa is to form a barrier that separates luminal contents
from the interstitium. The single layer of intestinal epithelial cells (IECs) serves as a dynamic …

The gut mucosa is constantly challenged by a bombardment of foreign antigens and
environmental microorganisms. As such, the precise regulation of the intestinal barrier …

Although the critical factors necessary for IBD pathogenesis remain mysterious, interest in
the potential role of defective epithelial barrier function continues to grow. New insight into …

The intestinal epithelium is a single-cell layer that constitutes the largest and most important
barrier against the external environment. It acts as a selectively permeable barrier …

The intestinal epithelium can be easily disrupted during gut inflammation as seen in
inflammatory bowel disease (IBD), such as ulcerative colitis or Crohn's disease. For a long …

The intestinal barrier is composed of several essential elements including luminal enzymes,
bile acids, water layer, epithelial layer, and enterocyte layer. It acts as a dynamic interface …

The complex interaction of genetic, microbial, and environmental factors may result in
continuous activation of the mucosal immune system leading to inflammatory bowel disease …