IMPLICATIONS: The antinociceptive effects of three novel depots of buprenorphine esters
were evaluated. We found that the novel depots of buprenorphine esters buprenorphine …

Transdermal buprenorphine is an effective analgesic for a variety of pain conditions.
Traditionally, neuropathic pain is treated with medications such as tricyclic antidepressants …

Buprenorphine, a powerful opioid, is newly available for delivery in a transdermal
formulation. The transdermal system's matrix patch provides rate-controlled administration of …

CONTEXT: This article presents the results of a pivotal Phase 3 study that assesses a new
treatment for the management of chronic low back pain: a transdermal patch containing the …

Background This multicenter, parallel-group, 35-day study in adults with osteoarthritis (OA)
pain evaluated the analgesic efficacy and safety of buprenorphine transdermal system …

Context Transdermal formulations of buprenorphine offer controlled delivery of
buprenorphine for sustained analgesic efficacy with reduced adverse events (AEs) …

Background: The clinical advantage of opioid rotation is probably due to incomplete cross‐
tolerance favouring analgesia more than adverse effects. The objectives of opioid rotation in …

Objective: A recent pharmacokinetic study with buprenorphine transdermal patches showed
similar systemic exposures of buprenorphine in subjects aged≥ 75 and 50–60 years. The …

The management of chronic pain remains a challenge because of its complexity and
unpredictable response to pharmacological treatment. In addition, accurate pain …

Background: Buprenorphine is a mixed-activity, partial μ-opioid agonist. Its lipid solubility
makes it well suited for transdermal administration. Objective: This study assessed the …