Genetic burden of dysregulated cytoskeletal organisation in the pathogenesis of pulmonary fibrosis

D Wang, Y Ni, B Liu, H Ding, A John, LV Wain… - bioRxiv, 2024 - biorxiv.org
Background Pulmonary fibrosis (PF) is a shared characteristic of chronic interstitial lung
diseases of mixed aetiology. Previous studies on PF highlight a pathogenic role for common …

Integrative analysis reveals the recurrent genetic etiologies in idiopathic pulmonary fibrosis

S Guo, Y Dong, C Wang, Y Jiang… - … Journal of Medicine, 2023 - academic.oup.com
Background Idiopathic pulmonary fibrosis (IPF) is increasingly recognized as a chronic,
progressive and fatal lung disease with an unknown etiology. Current studies focus on …

Integrative Analyses Reveal Novel Disease-associated Loci and Genes for Idiopathic Pulmonary Fibrosis

M Chen, Y Zhang, TS Adams, D Ji, W Jiang, LV Wain… - medRxiv, 2021 - medrxiv.org
Background Although genome-wide association studies have identified many genomic
regions associated with idiopathic pulmonary fibrosis (IPF), the causal genes and functions …

Mapping the genetic architecture of idiopathic pulmonary fibrosis: meta-analysis and epidemiological evidence of case-control studies

P Singh, D Guin, B Pattnaik, R Kukreti - Gene, 2023 - Elsevier
Background Idiopathic pulmonary fibrosis (IPF) is a rare and devastating fibrotic lung
disorder with unknown etiology. Although it is believed that genetic component is an …

Understanding the genetic basis of disease endotypes in idiopathic pulmonary fibrosis

LM Kraven - 2023 - figshare.le.ac.uk
Idiopathic pulmonary fibrosis (IPF) is a rare, incurable disease of unknown cause
characterised by progressive scarring of the lungs. The prognosis of IPF is poor with a …

Genetic landscape of idiopathic pulmonary fibrosis: A systematic review, meta-analysis and epidemiological evidence of case-control studies

P Singh, D Guin, B Pattnaik, R Kukreti - medRxiv, 2023 - medrxiv.org
Background: Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disorder of unknown cause,
affecting about three million people worldwide. Being a multifactorial disease, complex …

Idiopathic pulmonary fibrosis is associated with common genetic variants and limited rare variants

AL Peljto, RZ Blumhagen, AD Walts… - American journal of …, 2023 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a rare, irreversible, and progressive disease
of the lungs. Common genetic variants, in addition to nongenetic factors, have been …

Cluster analysis of transcriptomic datasets to identify endotypes of idiopathic pulmonary fibrosis

LM Kraven, AR Taylor, PL Molyneaux, TM Maher… - Thorax, 2023 - thorax.bmj.com
Background Considerable clinical heterogeneity in idiopathic pulmonary fibrosis (IPF)
suggests the existence of multiple disease endotypes. Identifying these endotypes would …

The genetic landscape of familial pulmonary fibrosis

Q Liu, Y Zhou, JD Cogan, DB Mitchell… - American Journal of …, 2023 - atsjournals.org
Rationale and Objectives: Up to 20% of idiopathic interstitial lung disease is familial, referred
to as familial pulmonary fibrosis (FPF). An integrated analysis of FPF genetic risk was …

Pulmonary fibrosis in the era of stratified medicine

SK Mathai, CA Newton, DA Schwartz, CK Garcia - Thorax, 2016 - thorax.bmj.com
Both common and rare variants contribute to the genetic architecture of pulmonary fibrosis.
Genome-wide association studies have identified common variants, or those with a minor …