Genetic burden of dysregulated cytoskeletal organisation in the pathogenesis of pulmonary fibrosis
Background Pulmonary fibrosis (PF) is a shared characteristic of chronic interstitial lung
diseases of mixed aetiology. Previous studies on PF highlight a pathogenic role for common …
diseases of mixed aetiology. Previous studies on PF highlight a pathogenic role for common …
Integrative analysis reveals the recurrent genetic etiologies in idiopathic pulmonary fibrosis
Background Idiopathic pulmonary fibrosis (IPF) is increasingly recognized as a chronic,
progressive and fatal lung disease with an unknown etiology. Current studies focus on …
progressive and fatal lung disease with an unknown etiology. Current studies focus on …
Integrative Analyses Reveal Novel Disease-associated Loci and Genes for Idiopathic Pulmonary Fibrosis
Background Although genome-wide association studies have identified many genomic
regions associated with idiopathic pulmonary fibrosis (IPF), the causal genes and functions …
regions associated with idiopathic pulmonary fibrosis (IPF), the causal genes and functions …
Mapping the genetic architecture of idiopathic pulmonary fibrosis: meta-analysis and epidemiological evidence of case-control studies
Background Idiopathic pulmonary fibrosis (IPF) is a rare and devastating fibrotic lung
disorder with unknown etiology. Although it is believed that genetic component is an …
disorder with unknown etiology. Although it is believed that genetic component is an …
Understanding the genetic basis of disease endotypes in idiopathic pulmonary fibrosis
LM Kraven - 2023 - figshare.le.ac.uk
Idiopathic pulmonary fibrosis (IPF) is a rare, incurable disease of unknown cause
characterised by progressive scarring of the lungs. The prognosis of IPF is poor with a …
characterised by progressive scarring of the lungs. The prognosis of IPF is poor with a …
Genetic landscape of idiopathic pulmonary fibrosis: A systematic review, meta-analysis and epidemiological evidence of case-control studies
Background: Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disorder of unknown cause,
affecting about three million people worldwide. Being a multifactorial disease, complex …
affecting about three million people worldwide. Being a multifactorial disease, complex …
Idiopathic pulmonary fibrosis is associated with common genetic variants and limited rare variants
AL Peljto, RZ Blumhagen, AD Walts… - American journal of …, 2023 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a rare, irreversible, and progressive disease
of the lungs. Common genetic variants, in addition to nongenetic factors, have been …
of the lungs. Common genetic variants, in addition to nongenetic factors, have been …
Cluster analysis of transcriptomic datasets to identify endotypes of idiopathic pulmonary fibrosis
Background Considerable clinical heterogeneity in idiopathic pulmonary fibrosis (IPF)
suggests the existence of multiple disease endotypes. Identifying these endotypes would …
suggests the existence of multiple disease endotypes. Identifying these endotypes would …
The genetic landscape of familial pulmonary fibrosis
Q Liu, Y Zhou, JD Cogan, DB Mitchell… - American Journal of …, 2023 - atsjournals.org
Rationale and Objectives: Up to 20% of idiopathic interstitial lung disease is familial, referred
to as familial pulmonary fibrosis (FPF). An integrated analysis of FPF genetic risk was …
to as familial pulmonary fibrosis (FPF). An integrated analysis of FPF genetic risk was …
Pulmonary fibrosis in the era of stratified medicine
SK Mathai, CA Newton, DA Schwartz, CK Garcia - Thorax, 2016 - thorax.bmj.com
Both common and rare variants contribute to the genetic architecture of pulmonary fibrosis.
Genome-wide association studies have identified common variants, or those with a minor …
Genome-wide association studies have identified common variants, or those with a minor …