T2 Cluster analysis of transcriptomic datasets to identify endotypes of idiopathic pulmonary fibrosis

LM Kraven, AR Taylor, PL Molyneaux, TM Maher… - 2021 - thorax.bmj.com
Rationale Considerable clinical heterogeneity in Idiopathic Pulmonary Fibrosis (IPF)
suggests the existence of multiple disease endotypes. Identifying these endotypes could …

Pulmonary fibrosis in the era of stratified medicine

SK Mathai, CA Newton, DA Schwartz, CK Garcia - Thorax, 2016 - thorax.bmj.com
Both common and rare variants contribute to the genetic architecture of pulmonary fibrosis.
Genome-wide association studies have identified common variants, or those with a minor …

Integrative analyses for the identification of idiopathic pulmonary fibrosis-associated genes and shared loci with other diseases

M Chen, Y Zhang, T Adams, D Ji, W Jiang, LV Wain… - Thorax, 2023 - thorax.bmj.com
Background Although genome-wide association studies (GWAS) have identified many
genomic regions associated with idiopathic pulmonary fibrosis (IPF), the causal genes and …

[HTML][HTML] Integrative analysis of lung molecular signatures reveals key drivers of idiopathic pulmonary fibrosis

SK Kim, SM Jung, KS Park, KJ Kim - BMC Pulmonary Medicine, 2021 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a devastating disease with a high clinical
burden. The molecular signatures of IPF were analyzed to distinguish molecular subgroups …

Genetics of idiopathic pulmonary fibrosis: from mechanistic pathways to personalised medicine

P Spagnolo, V Cottin - Journal of medical genetics, 2017 - jmg.bmj.com
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and ultimately fatal disorder for
which there is no cure. While the disease is by definition idiopathic, accumulating evidence …

Genetic and Lifestyle Risk Factors for Idiopathic Pulmonary Fibrosis: Greater Than the Sum of Its Parts

CA Newton - Chest, 2023 - journal.chestnet.org
Extensive efforts have provided clarity regarding the complex genetic architecture
underlying idiopathic pulmonary fibrosis (IPF). A multitude of genes and variants have been …

Genome-wide association study of susceptibility to idiopathic pulmonary fibrosis

RJ Allen, B Guillen-Guio, JM Oldham… - American journal of …, 2020 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by
scarring of the lung that is believed to result from an atypical response to injury of the …

Gene correlation network analysis to identify regulatory factors in idiopathic pulmonary fibrosis

JE McDonough, N Kaminski, B Thienpont, JC Hogg… - Thorax, 2019 - thorax.bmj.com
Background Idiopathic pulmonary fibrosis (IPF) is a severe lung disease characterised by
extensive pathological changes. The objective for this study was to identify the gene network …

[HTML][HTML] Detecting the molecular system signatures of idiopathic pulmonary fibrosis through integrated genomic analysis

I Gangwar, N Kumar Sharma, G Panzade, S Awasthi… - Scientific reports, 2017 - nature.com
Abstract Idiopathic Pulmonary Fibrosis (IPF) is an incurable progressive fibrotic disease of
the lungs. We currently lack a systematic understanding of IPF biology and a systems …

[HTML][HTML] Consensus gene co-expression network analysis identifies novel genes associated with severity of fibrotic lung disease

S Ghandikota, M Sharma, HH Ediga… - International Journal of …, 2022 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a severe fibrotic lung disease characterized by
irreversible scarring of the lung parenchyma leading to dyspnea, progressive decline in lung …