Use of biological therapies for the management of pustular psoriasis: a new era?

M Megna, E Camela, A Ruggiero… - Clinical, cosmetic and …, 2023 - Taylor & Francis
Generalized pustular psoriasis (GPP) is a severe and rare form of psoriasis, being a
potentially life-threatening condition, characterized by recurring episodes or flares of …

Efficacy and safety of spesolimab for the management of generalized pustular psoriasis: a drug safety evaluation

L Potestio, E Camela, S Cacciapuoti… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Generalized pustular psoriasis (GPP) is a rare form of psoriasis (less of 1% of
cases). Currently, GPP is recognized as a clinical entity, distinguished from plaque psoriasis …

[HTML][HTML] Spesolimab for the treatment of generalized pustular psoriasis

D Bernardo, D Thaçi, T Torres - Drugs, 2024 - Springer
Generalized pustular psoriasis (GPP) is a rare but severe skin inflammatory disorder
characterized by the eruption of widespread sterile neutrophilic pustules, often accompanied …

[HTML][HTML] Pustular psoriasis: a narrative review of recent developments in pathophysiology and therapeutic options

A Menter, AS Van Voorhees, S Hsu - Dermatology and Therapy, 2021 - Springer
Pustular psoriasis is an unusual form of psoriasis that frequently presents clinical challenges
for dermatologists. The condition presents with pustules on an erythematous background …

Generalized pustular psoriasis–a model disease for specific targeted immunotherapy, systematic review

A Boehner, AA Navarini, K Eyerich - Experimental dermatology, 2018 - Wiley Online Library
Generalized pustular psoriasis (GPP) is a rare, multisystemic skin disease characterized by
recurrent episodes of pustulation. GPP can be life‐threatening and is often difficult to treat. In …

Generalized pustular psoriasis: the new era of treatment with IL-36 receptor inhibitors

CO Maçães, AM Lé, T Torres - Journal of Dermatological Treatment, 2022 - Taylor & Francis
Generalized pustular psoriasis (GPP) is a rare yet severe variant of psoriasis, characterized
by the eruption of superficial sterile pustules that appear suddenly and widely distributed …

[HTML][HTML] Design of Effisayil™ 2: a randomized, double-blind, placebo-controlled study of spesolimab in preventing flares in patients with generalized pustular psoriasis

A Morita, SE Choon, H Bachelez, MJ Anadkat… - Dermatology and …, 2023 - Springer
Introduction Generalized pustular psoriasis (GPP) is a rare autoinflammatory skin disease
characterized by flares of widespread erythema with sterile pustules, and can be relapsing …

Current management of generalized pustular psoriasis

N Kodali, I Blanchard, S Kunamneni… - Experimental …, 2023 - Wiley Online Library
Generalized pustular psoriasis (GPP) is a rare subset of psoriasis involving episodes of
sterile pustules accompanied by inflammation and, often, systemic involvement. The …

Efficacy of spesolimab for the treatment of generalized pustular psoriasis flares across pre‐specified patient subgroups in the Effisayil 1 study

AD Burden, Y Okubo, M Zheng, D Thaçi… - Experimental …, 2023 - Wiley Online Library
Effisayil 1 was a multicentre, randomized, double‐blind, placebo‐controlled study of the anti‐
interleukin (IL)‐36 receptor monoclonal antibody, spesolimab, in patients presenting with a …

An update on generalized pustular psoriasis

MJ Gooderham, AS Van Voorhees… - Expert review of clinical …, 2019 - Taylor & Francis
Introduction: Generalized pustular psoriasis (GPP) is a rare, severe relapsing/remitting,
multisystem disease that can be difficult to treat. Recent clinical, histological, and genetic …