Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease,
Huntington's disease, and amyotrophic lateral sclerosis are a heterogeneous group of …

Alzheimer's disease (AD) is a debilitating neurodegenerative disorder characterized by the
progressive loss of cholinergic neurons, leading to the onset of severe behavioral, motor …

Bioenergetic and mitochondrial dysfunction are common hallmarks of neurodegenerative
diseases. Decades of research describe how genetic and environmental factors initiate …

Alzheimer's disease (AD) is an increasingly pressing worldwide public-health, social,
political and economic concern. Despite significant investment in multiple traditional …

Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and
characterized by the progressive degeneration of the function and structure of the central …

In recent years, multiple disciplines have focused on mitochondrial biology and contributed
to understanding its relevance towards adult-onset neurodegenerative disorders. These are …

The sustained integrity of the mitochondrial population of a cell is critical for maintained cell
health, and disruption of that integrity is linked strongly to human disease, especially to the …

Background: Mitochondrial function and energy metabolism are impaired in
neurodegenerative diseases. There is evidence for these functional declines both within the …

Mitochondria are critical for homeostasis and metabolism in all cellular eukaryotes. Brain
mitochondria are the primary source of fuel that supports many brain functions, including …

Mitochondria are associated with various cellular activities critical to homeostasis,
particularly in the nervous system. The plastic architecture of the mitochondrial network and …