Sepsis is a major health problem and a leading cause of death worldwide. In recent years, a
crescendo of attention has been directed to the mechanisms of cell death that develop …

The complex immune response associated with sepsis results in a high rate of morbidity and
mortality, despite substantial basic science and clinical advances. Most of the research has …

Sepsis is a life-threatening medical condition that occurs when the host has an uncontrolled
or abnormal immune response to overwhelming infection. It is now widely accepted that …

Dysregulated apoptotic cell death contributes to many pathological conditions, including
sepsis, prompting the suggestion that caspase inhibition to block apoptosis could have …

Sepsis is a systemic inflammatory response induced by an infection, leading to organ
dysfunction and mortality. Historically, sepsis-induced organ dysfunction and lethality were …

Multiorgan apoptosis occurs during sepsis. Following cecal ligation and puncture (CLP) in
rats, thymocytes underwent apoptosis in a time-dependent manner. C5a blockade …

Sepsis is a syndrome related to severe infections. It is defined as the systemic host response
to microorganisms in previously sterile tissues and is characterized by end-organ …

Surgical injury can be a life‐threatening complication, not only due to the injury itself, but
also due to immune responses to the injury and subsequent development of infections …

Sepsis remains the leading cause of death in most intensive care units. Advances in
understanding the immune response to sepsis provide the opportunity to develop more …

Cell death research during the last decades has revealed many molecular signaling
cascades, often leading to distinct cell death modalities followed by immune responses. For …