In vertebrate cells, the nucleoporin Nup358/RanBP2 is a major component of the filaments
that emanate from the nuclear pore complex into the cytoplasm. Nup358 forms a complex …

The importin‐alpha/beta heterodimer and the GTPase Ran play key roles in nuclear protein
import. Importin binds the nuclear localization signal (NLS). Translocation of the resulting …

The importin-α/β complex and the GTPase Ran mediate nuclear import of proteins with a
classical nuclear localization signal. Although Ran has been implicated also in a variety of …

▪ Abstract A central aspect of cellular function is the proper regulation of nucleocytoplasmic
transport. In recent years, significant progress has been made in identifying and …

RNA export from the nucleus can be divided into two general phases. The first involves
ribonucleoprotein (RNP) movement from the site of RNA transcription and RNP assembly to …

Three independent pathways of nuclear import have so far been identified in yeast, each
mediated by cognate nuclear transport factors, or karyopherins. Here we have characterized …

The assembly of eukaryotic ribosomal subunits takes place in the nucleolus and requires
nuclear import of ribosomal proteins. We have studied this import in a mammalian system …

Signaling pathways consist of a chain of biochemical events that form the intracellular
equivalent of a fire bucket brigade. An initial change or chemical signal outside the cell is …

Importin-α mediates nuclear protein import by binding nuclear localization signals and
importin-β. We find approximately 30% of SRP1p, the yeast importin-α, in a nuclear complex …

The nuclear import of proteins into the cell nucleus involves the recognition of a nuclear
localization signal sequence, borne by the protein to be transported, by complex molecules …