All major nuclear export pathways so far examined follow a general paradigm 1, 2, 3.
Specifically, a complex is formed in the nucleus, containing the export cargo, a member of …

In eukaryotic cells, segregation of DNA replication and RNA biogenesis in the nucleus and
protein synthesis in the cytoplasm poses the requirement of transporting thousands of …

Specific and efficient recognition of import cargoes is essential to ensure nucleocytoplasmic
transport. To this end, the prototypical karyopherin importin β associates with import cargoes …

We have purified a cytosolic protein from Xenopus eggs that is essential for selective protein
import into the cell nucleus. The purified protein, named importin, promotes signal …

Abstract The GTPase Ran is essential for nuclear import of proteins with a classical nuclear
localization signal (NLS). Ran's nucleotide‐bound state is determined by the chromatin …

Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is an abundant nuclear protein that
plays an important role in pre-mRNA processing and mRNA export from the nucleus. A1 …

The import of proteins into the nucleus is dependent on cis-acting targeting sequences,
nuclear localization signals (NLSs), and members of the nuclear transport receptor (importin …

The “classical” nuclear protein import pathway depends on importin α and importin β.
Importin α binds nuclear localization signal (NLS)-bearing proteins and functions as an …

NLS proteins are transported into the nucleus by the importin α/β heterodimer. Importin α
binds the NLS, while importin β mediates translocation through the nuclear pore complex …

Import of proteins containing a classical nuclear localization signal (NLS) into the nucleus is
mediated by importin α and importin β. Srp1p, the Saccharomyces cerevisiae homologue of …