Transport of macromolecules across the nuclear envelope is an active process that depends
on soluble factors including the GTPase Ran. Ran-GTP is predominantly located in the …

A major question in nuclear import concerns the identity of the nucleoporin (s) that interact
with the nuclear localization sequences (NLS) receptor and its cargo as they traverse the …

In eukaryotic cells, there is continuous exchange of macromolecules between the
nucleoplasm and the cytoplasm. Transport in both directions occurs through nuclear pore …

The use of permeabilized cell models to study nuclear protein import has led to the
identification of cytosolic components of the import machinery, including the NLS receptor …

CRM1 is distantly related to receptors that mediate nuclear protein import and was
previously shown to interact with the nuclear pore complex. Overexpression of CRM1 in …

In eukaryotes, tRNAs are synthesized in the nucleus and after several maturation steps
exported to the cytoplasm. Here, we identify exportin-t as a specific mediator of tRNA export …

Most nucleocytoplasmic traffic through the nuclear pore complex is mediated by soluble
receptors of the importin/exportin or karyopherin family. mRNA export is unique in that no …

Protein transport into the nucleus is governed by the interaction of soluble transport factors
with their import substrates and nuclear pore complexes. Here, we identify a major distinct …

The complex of importin‐alpha and‐beta is essential for nuclear protein import. It binds the
import substrate in the cytosol, and the resulting trimeric complex moves through the nuclear …

Import of proteins into the nucleus proceeds through nuclear pore complexes and is largely
mediated by nuclear transport receptors of the importin β family that use direct RanGTP …