Structural imaging of hippocampal subfields in healthy aging and Alzheimer's disease

R De Flores, R La Joie, G Chételat - Neuroscience, 2015 - Elsevier
Hippocampal atrophy, as evidenced using magnetic resonance imaging (MRI), is one of the
most validated, easily accessible and widely used biomarkers of Alzheimer's disease (AD) …

Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease

SG Mueller, N Schuff, K Yaffe, C Madison… - Human brain …, 2010 - Wiley Online Library
Background: Histopathological studies and animal models suggest that hippocampal
subfields may be differently affected by aging, Alzheimer's disease (AD), and other diseases …

Trajectories of the hippocampal subfields atrophy in the Alzheimer's disease: a structural imaging study

W Zhao, X Wang, C Yin, M He, S Li… - Frontiers in …, 2019 - frontiersin.org
Background The hippocampus and hippocampal subfields have been found to be diversely
affected in Alzheimer's Disease (AD) and early stages of Alzheimer's disease by …

[HTML][HTML] Hippocampal subfield volumetry in mild cognitive impairment, Alzheimer's disease and semantic dementia

R La Joie, A Perrotin, V de La Sayette, S Egret… - NeuroImage: Clinical, 2013 - Elsevier
Background Hippocampal atrophy is a well-known feature of Alzheimer's disease (AD), but
sensitivity and specificity of hippocampal volumetry are limited. Neuropathological studies …

Differential effect of age on hippocampal subfields assessed using a new high-resolution 3T MR sequence

R La Joie, M Fouquet, F Mézenge, B Landeau… - Neuroimage, 2010 - Elsevier
Recent advances in neuroimaging have highlighted the interest to differentiate hippocampal
subfields for cognitive neurosciences and more notably in assessing the effects of normal …

Effects of age and Alzheimer's disease on hippocampal subfields: comparison between manual and FreeSurfer volumetry

R de Flores, R La Joie, B Landeau… - Human brain …, 2015 - Wiley Online Library
Growing interest has developed in hippocampal subfield volumetry over the past few years
and an increasing number of studies use the automatic segmentation algorithm …

In vivo analysis of hippocampal subfield atrophy in mild cognitive impairment via semi-automatic segmentation of T2-weighted MRI

J Pluta, P Yushkevich, S Das… - Journal of Alzheimer's …, 2012 - content.iospress.com
The measurement of hippocampal volumes using MRI is a useful in-vivo biomarker for
detection and monitoring of early Alzheimer's disease (AD), including during the amnestic …

Automated hippocampal subfield measures as predictors of conversion from mild cognitive impairment to Alzheimer's disease in two independent cohorts

W Khan, E Westman, N Jones, LO Wahlund, P Mecocci… - Brain topography, 2015 - Springer
Previous studies have shown that hippocampal subfields may be differentially affected by
Alzheimer's disease (AD). This study used an automated analysis technique and two large …

Nearly automatic segmentation of hippocampal subfields in in vivo focal T2-weighted MRI

PA Yushkevich, H Wang, J Pluta, SR Das, C Craige… - Neuroimage, 2010 - Elsevier
We present and evaluate a new method for automatically labeling the subfields of the
hippocampal formation in focal 0.4× 0.5× 2.0 mm3 resolution T2-weighted magnetic …

Hippocampal-subfield microstructures and their relation to plasma biomarkers in Alzheimer's disease

SS Shahid, Q Wen, SL Risacher, MR Farlow… - Brain, 2022 - academic.oup.com
Hippocampal subfields exhibit differential vulnerabilities to Alzheimer's disease-associated
pathology including abnormal accumulation of amyloid-β deposition and neurofibrillary …