The nasal cavity has been used as a route of drug administration for many decades for
topical therapies and more recently for systemic delivery. Several factors should be taken …

Background In nasal drug delivery system, nasal spray seems to be the most promising
delivery method for both local and systemic diseases therapy. Nasal deposition behavior is …

Background: Previous studies showed nasal spray in vitro tests cannot predict in vivo
deposition, pharmacokinetics, or pharmacodynamics. This challenge makes it difficult to …

In this study, the effects of nasal drug delivery device and the spray nozzle orientation on
sprayed droplets deposition in a realistic human nasal cavity were numerically studied. Prior …

Validating numerical models against experimental models of nasal spray deposition is
challenging since many aspects must be considered. That being said, it is a critical step in …

Purpose To systematically evaluate the effect of formulation-and administration-related
variables on nasal spray deposition using a nasal cast. Methods Deposition pattern was …

A mathematical approach was developed to estimate spray deposition patterns in the nasal
cavity based on the geometric relationships between the emitted spray plume and the …

Nasal spray can treat local diseases such as rhinitis, it also plays an important role in the
treatment of systemic diseases including vaccine immunity. As a drug-device combination …

Purpose This study was conducted to evaluate the effect of formulation variables and
breathing patterns on aerosol distribution in the nasal cavity. Methods Placebo nasal spray …

Nasal nebulization is a more effective method of delivering topical medication than nasal
spray. The purpose of this study was to assess the deposition patterns of nebulization in …